丝/苏氨酸激酶Pim-3基因对急性肝功能衰竭肝保护效应的实验研究
被引量：2
摘要
急性肝功能衰竭（ALF）是常见的临床急重病症，缺乏特殊有效的治疗药物，现基因治疗成为该病治疗研究的热点。作为丝/芬氨酸激酶Pim家族的重要成员，Pim-3基因在细胞生长通路中起重要作用，已知Pim-3基因在损伤周围组织和增殖活跃的肝组织内均出现极高水平的表达。这提示Pim-3基因可能在损伤肝组织的修复中扮演重要角色。
出处
《中华消化杂志》
CAS
CSCD
北大核心
2006年第9期625-626,共2页
Chinese Journal of Digestion
基金
国家自然科学基金(30360037)
参考文献5
-
1Lu A,Tang Y,Ran R,et al.Genomics of the periinfarction cortex after focal cerebral ischemia.J Cereb Blood Flow Metab,2003,23:786-810.
-
2Fujii C,Nakamoto Y,Lu P,et al.Aberrant expression of serine/threonine kinase pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines.Int J Cancer,2005,114:209-218.
-
3Galanos C,Freudenberg MA,Reutter W.Galactosamine induced sensitization to the lethal effects of endotoxin.Proc Natl Acad Sci USA,1979,76:5939-5943.
-
4Liu F,Song Y,Liu D.Hydrodynamics-based transfection in animals by systemic administration of plasmid DNA.Gene Ther,1999,6:1258-1266.
-
5Doggrell SA.Suramin:potential in acute liver failure.Expert Opin Investig Drugs,2004,13:1361-1363.
同被引文献11
-
1Jin-mingDAI,Shu-qunZHANG,WeiZHANG,Ru-xianLIN,Zong-zhengJI,Sheng-qiWANG.Antisense oligodeoxynucleotides targeting the serine/threonine kinase Pim-2 inhibited proliferation of DU-145 cells[J].Acta Pharmacologica Sinica,2005,26(3):364-368. 被引量：9
-
2李龙标,陆培荣,张学光.丝/酪氨酸蛋白激酶PIM3在小鼠眼部组织的表达及分布[J].苏州大学学报（医学版）,2006,26(5):734-737. 被引量：1
-
3Zanet J, Pibre S, Jacquet C, et al. Endogenous Myc controls mammalian epidermal cell size, hyperproliferation, endoreplication and stem cell amplication[J]. J Cell Sci, 2005, 118(Pt 8): 1693-1704.
-
4Lee Y, Gustafsson AB. Role of apoptosis in cardiovascular disease [J]. Apoptosis ,2009, 14(1): Epub ahead of print.
-
5Spector DL, Goldman RD, Leinwand LA. Culture and biochemical analysis of cells [M]. In: Barker P ed. Cells: a laboratory manual. New York: Cold Spring Harbor Laboratory Press, 1998:11.1-11.6.
-
6Xu M, Wang YG, Kyoji H, et al. Calcium preconditioning inhibits mitocbondrial permeability transition and apeptosis[J]. Am J Physiol Heart Circ Physiol, 2001, 280(2): 899-908.
-
7Kluck RM, Bossy-Wetzel E. Green DD, et al. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis[J]. Science, 1997, 275(5305): 1132-1136.
-
8Peng C, Knebel A, Mortice NA, et al. Pim kinase substrate identification and specificity[J]. J Biochem, 2007, 141(3): 353-362.
-
9He A, Wang JA, Gui C, et aI.Changes of mitochondrial pathway in hypoxia/reoxygenation induced cardiomyocytes apoptosis [J]. Folia Histochem Cytobiol, 2007, 45(4): 397-400.
-
10Lakhani SA, Masud A, Kuida K, et al. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis [J]. Science, 2006, 311 (5762): 785-786.
引证文献2
-
1李小燕,朱水山,刘亮明,黄缘.pim-3基因的分子生物学特性及作用[J].医学分子生物学杂志,2008,5(2):146-148. 被引量：2
-
2刘丹,何明,易波,阙爱玲,徐江晶,张吉翔.细胞色素C在Pim-3抗心肌急性损伤中的作用[J].天津医药,2009,37(11):941-943.
-
1徐斌.上消化道出血72例急诊胃镜诊治分析[J].中国误诊学杂志,2009,9(7):1661-1662. 被引量：12
-
2李金锋,王化云.老年人非典型急性心肌梗死临床误诊分析[J].中外医疗,2010,29(26):83-83.
-
3石云章.中西医结合治疗冠心病心绞痛31例[J].国医论坛,2009,24(3):30-31.
-
4林庆育,林群英.无创正压通气在26例COPD合并呼吸衰竭中的应用[J].福建医药杂志,2008,30(1):57-58.
-
5郑运民.中西药治疗肺结核咯血30例观察[J].现代中西医结合杂志,2001,10(14):1362-1362.
-
6李健民.硝酸甘油和多巴酚丁胺治疗心衰疗效观察[J].中国城乡企业卫生,2006,21(5):26-26.
-
7黄岩,李杰,王东萍.心衰患者应用华法令应注意的药物相互作用[J].世界医学杂志,2004,8(7):40-42. 被引量：1
-
8刘静,张林,冯英凯.高原肺水肿患者焦虑评估与护理干预效果[J].重庆医学,2012,41(19):2001-2002. 被引量：2
-
9邹施文.两种常见心绞痛的中医疗法[J].求医问药,2011(8):48-48.
-
10黄国进,田元军,陆志平.中西医治疗急性胰腺炎临床分析[J].临床医学,2004,24(2):42-43.
