摘要
目的:探讨c-Fos,c-Jun,Bcl-2在胃癌中的表达与胃癌的发生、发展及生物学行为的关系．方法:应用免疫组织化学SABC法,检测54例胃癌及癌旁组织中c-Fos,c-Jun,Bcl-2蛋白的表达,结果采用SPSS统计软件包及X2检验分析．结果:胃癌组织中c-Fos,c-Jun,Bcl-2的表达显著高于癌旁组织(68．5％vs 27．8％,X2=17．95, P<0．01;63．0％vs 24．1％,X2=16．61,P<0．01; 64．8％vs 25．9％,X2=16．48,P<0．01)．c-Fos, c-Jun的表达在胃癌不同组织学分级间有显著性差异(P=0．018;P=0．032),在淋巴结转移、TNM分期间无显著性差异;Bcl-2的表达在胃癌不同组织学分级、淋巴结转移、TNM分期间有显著性差异(P=0．035;P=0．032;P =0．009)．胃癌及癌旁组织中Bcl-2与c-Fos、c-Jun(r=0．336,0．688,P<0．05;r=0．318, 0．512,P<0．05)及c-Fos与c-Jun(r=0．719,0．586, P<0．001)之间的表达呈正相关．结论:c-Fos,c-Jun,Bcl-2的表达与胃癌的发生、发展以及组织学分级密切相关．
AIM： To detect the expression of c-Fos, c-Jun and Bcl-2 protein in gastric carcinoma and explore their correlations with the development and biological behavior of gastric carcinoma. METHODS： SABC immunohistochemistry was used to detect the expressions of c-Fos, c-Jun and Bcl-2 protein in specimens （n =54） from gastric carcinoma and the corresponding canceradjacent tissues. The data were analyzed by Chi- Square test using SPSS software. RESULTS： The positive rates of c-Fos, c-Jun and Bcl-2 expression were significantly higher in cancer tissues than those in cancer-adjacent ones （68.5% vs 27.8%, ;（2 = 17.95, P 〈 0.01; 63.0% vs 24.1%, ;χ^2=16.61, P 〈 0.01; 64.8% vs 25.9%, χ^2= 16.48, P 〈 0.01）. The significant difference was present in the expression of c-Fos and c-Jun among different histological types （P = 0.018; P = 0.032）, but wasn＇t among different status of regional lymph node metastasis and TNM stages. Bcl-2 expression was markedly different among different histological types, status of regional lymph node metastasis and TNM stages （P = 0.035; P = 0,032; P = 0.009）. There was a posifive correlation between expression of Bcl-2 and c-Fos （r = 0.336, 0.688, P 〈 0.05）, Bcl-2 and c-Jun （r = 0.318, 0.512, P 〈 0.05） as well as between c-Fos and c-Jun （r = 0.719, 0.586, P 〈 0.001）. CONCLUSION： The expression of c-Fos, c-Jun and Bcl-2 are closely correlated with the carcinogenesis, development, and histological types.
出处
《世界华人消化杂志》
CAS
北大核心
2006年第24期2448-2451,共4页
World Chinese Journal of Digestology
