摘要
目的:探讨肝硬化并胆囊结石的临床特点及其发病机制．方法:回顾性分析我院2003-2／2006-2住院的131例肝硬化患者,并以同期门诊行体检者790例作为对照组,分析的指标包括肝硬化并胆囊结石患者的性别差异、与对照组性别差异、肝病性胆囊改变在肝硬化胆囊结石发生中的作用、肝硬化并脾功能亢进在肝硬化胆囊结石发生中的作用．结果:肝硬化胆囊结石的发生率为41．22％,对照组胆结石的发生率为6．96％;肝硬化患者胆囊结石的发生率无性别差异(P>0．05);男性与女性肝硬化患者与对照组比较,胆囊结石发生率均有显著差异(39．58％vs 5％,P<0．05; 48．57％vs 10．53％,P<0．05);肝病性胆囊改变及肝硬化并脾功能亢进在胆囊结石发生中起着重要作用．肝病性胆囊改变患者胆囊结石发病率明显高于无肝病性胆囊改变者(48．39％vs 26．32％,P<0．05),肝硬化并脾功能亢进胆囊结石的发生率与对照组比较差异也有显著性(54．44％vs 6．96%,P<0．05)．结论:肝硬化患者易发生胆囊结石,与性别无关而与肝功能、胆囊运动功能障碍、脾功能亢进等有关．
AIM： To investigate the clinical characteristics and the formation causes of gallstone complicated with liver cirrhosis. METHODS： We retrospectively analyzed 131 patients with hepatic cirrhosis from February, 2003 to February, 2006. Meanwhile, 790 cases received medical examination served as the controls. Sexual differences, gallbladder abnormity and hypersplenism were assessed by Chi-square test. RESULTS： The incidence rate of hepatocirrhosis associated with gallstone was 41.22%. In the controls, the incidence rate of gallstone was 6.96%. The morbidity rate did not differ between the males and females with cirrhosis （P 〉 0.05）, but it significantly differed between the patients with cirrhosis and the controls among the males （39.58% vs 5%, P 〈 0.05） and females （48.57% vs 10.53%, P 〈 0.05）. The incidence rate of gallstone in patients with gallbladder abnormity complicated with hepatocirrhosis was significantly higher than that in ones without cirrhosis （48.39% vs 26.32%, P 〈 0.05）, and the incidence rate was also significantly different between the patients with hypersplenism and the controls （54.44 % vs 6.96%, P 〈 0.05）. CONCLUSION： Gallstone frequently occurs in patients with liver cirrhosis, which has no correlation with the sex of patients, but correlates with liver function, dysfunction of gallbladder motility, and hypersplenism.
出处
《世界华人消化杂志》
CAS
北大核心
2006年第24期2456-2459,共4页
World Chinese Journal of Digestology
关键词
肝硬化
胆囊结石
肝功能
脾功能亢进
Hepatocirrhosis
Gallstone
Liver function
Hypersplenism
