摘要
目的评价雾化吸入盐酸戊乙奎醚(长托宁)在COPD急性发作期降低肺动脉压及改善肺功能的疗效。方法将60例COPD急性发作期患者随机分为两组：治疗组30例．对照组30例,治疗组雾化吸入长托宁,对照组雾化吸入喘定。分别测定两组患者用药前后不同时期最大呼气流速(PEF)、第一秒用力呼气量(FEV1),动脉血气的变化及超声心动测定肺动脉压的变化。结果治疗组肺动脉压下降约20%,对照组肺动脉压下降约5%,两组比较差异有显著性(P＜0．01)。治疗组FEV1和PEF改善,两组比较有显著性(P＜0．05)。治疗组动脉血气明显改善,PaO_2上升18mmHg(P＜0．01),与对照组比较差异有显著性,PaCO_2前后对比差异无统计学意义(P＞0．05)。且咳嗽、咳痰等症状均明显改善。结论长托宁在改善AECOPD患者的症状、降低肺动脉压从而改善肺功能方面具有较好的疗效。
Objective To evaluate the efficiency of inhaling penehyclidine hydyochloride （PHC） in reducing pulmonary arterial pressure and improving lung function in patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD）. Methods Sixty patients with AECOPD were randomly divided into the control group （30 patients） and the treatment group （30 patients）. The patients in treatment group inhaled PHC, and patients in control group inhaleel diprophyUine. The pulmonary arterial pressure was measured before and after inhalation. The peak expiratory flow （PEF） and forced expiratory volume in one second （ FEV1 ） was measured at different time points before and after inhalation. Arterial blood gas and, symptoms were also observed. Results The pulmonary arterial pressure in treatment group was reduced by 20% and reduced by 5% in the control group. FEV1 and PEF were improved after inhalation, the average increased FEV1 was 350 ml （ P 〈 0.01）, and PEF was improved by 37 L/min （ P 〈 0.05）. Arterial blood gas analysis was improved, and PaO2 increased by 18 mmHg （ P 〈 0.01 ）. The respiratory rate and the symptoms of cough and sputum were also improved. Conclusion PHC improved the lung function of patients with AECOPD by reducing the pulmonary arterial pressure.
出处
《中华急诊医学杂志》
CAS
CSCD
2006年第10期909-912,共4页
Chinese Journal of Emergency Medicine
关键词
盐酸戊乙奎醚
慢性阻塞性肺疾病
急性加重期
肺功能
肺动脉压
Penehyclidine hydyochloride
Chronic obstructive pulmonary disease
Acute exacerbation
Lung function
Pulmonary arterial pressure
