摘要
目的:分析连云港地区新生儿先天性甲状腺功能低下症(CH)的发生、分布及临床流行病学特征。方法:采用干血滤纸片法,对107 991例出生72 h的新生儿采集足跟血,酶联免疫吸附法或时间分辨免疫荧光法检测血片中促甲状腺激素(TSH)水平,并对确诊患儿进行临床流行病学调查。结果:CH筛查阳性率为40.74/10万(44/107 991,1/2 454),临床流行病学调查44例患儿分布在全市的33个乡镇(街道),其中有11个乡(镇)各有2例CH患儿,在男女性别和城乡分布均无显著性差异(P>0.05),未见近亲结婚和遗传家族史。母孕期正常的CH病儿有32例(72.73%)新生儿黄疸延迟。结论:CH在连云港地区呈散发性分布,而非地方性CH。进行新生儿筛查是发现CH的有效手段。使病儿得到早期诊治,是提高我国人口素质的重要措施。
Objective： To study the incidence, distribution and clinical epidemiology of neonatal congenital hypothyroidism （CH） in Lianyungang. Methods： Heel blood specimens dried on filter paper were collected from 107 991 newborns after 72 hours to detect the TSH in blood by ELISA and TRFIA, and to investigate the clinical epidemiology of CH patients diagnosed. Results： The positive rate of CH screening was 1 ： 2 454 . To investigate the clinical epidemiology of 44 patients distributed in 33 towns （streets） of the city, above that, there were each 2 CH patients in 1 l towns, no difference existed in sex or city and town distribution, no propinquity married and no history of heredity family existed. 32 in 44 CH patients whose mothers had normal pregnancy had neonatal jaundice delayed. Conclusion： The distribution of CH is diffused not endemic in Lianyungang. The neonatal CH screening is the effective means to find out CH. It is an important measure that treat CH patients early to improve the population quality in our country.
出处
《中国妇幼保健》
CAS
北大核心
2006年第19期2693-2695,共3页
Maternal and Child Health Care of China
