摘要
目的：探讨氨茶碱所致不良反应的一般规律及特点。方法：对1994～2005年氨茶碱不良反应12年间的国内文献源应用Excel软件进行统计分析。结果：氨茶碱的不良反应大多在用药1d内发生。不良反应以循环系统和神经系统损害为主,分别占不良反应总例数的41．75%和33．98%,其次为呼吸系统的不良反应。不良反应预后除两例未提及,其余101例有89．11%的患者可痊愈或好转,1．98%的患者留有后遗症,但仍有8．91%的患者死亡。结论：氨茶碱不良反应涉及多个系统,所以应合理应用氨茶碱,重视药物不良反应的临床监测,确保用药安全,尽量减少不良反应的发生。
Objective： To explore the rules and characteristics of adverse drug reaction （ADR） of aminophylline. Method： A statistical analysis was made of ADR of aminophylline reported in domestic literatures from 1994 to 2005. Resuit： The ADR of aminophylline commonly appeared within 1 day after the administration. The ADR appeared most frequently in the circulatory system and nervous system, and more frequently in the respiratory system. The outcome of ADR showed that 89.11% of the patients could fully recover or improve, but 1.98% had their sequelae, and 8.91% died, Condusion： Aminophylline is widely .used in clinical therapy and their ADR is comprehensive. So it is important to pay more attention to rational use of aminophylline and enhance the clinical monitoring, The safety in the clinical aminophylline application should be ensured.
出处
《药物流行病学杂志》
CAS
2006年第5期279-281,共3页
Chinese Journal of Pharmacoepidemiology
关键词
氨茶碱
药物不良反应
文献分析
Aminophylline
Adverse drug reaction
Literatures analysis
