摘要
报道1例先天性持续性高胰岛素性低血糖症患儿的临床诊治情况。患儿，男，孕36周，因“胎儿宫内窘迫”剖宫产出生，出生体重4200g，生后即表现为反复低血糖，加用糖皮质激素治疗后患儿的血糖仍一直波动于1．2～2．8mmol／L之间，需静脉输注10％葡萄糖溶液，糖速为10～17mg／（kg·min），才能维持血糖的稳定。生后30d测定血胰岛素浓度为24．13U／L，同份标本的血糖为1．5mmol／L，血浆胰岛素（U／L）／血浆葡萄糖（mg／dL）比值为0．89，表明体内存在器质性胰岛素不适当分泌过多，诊断为先天性高胰岛素血症。
This paper reported a case of congenital hyperinsulinism and reviewed the relevant literatures regarding to the etiology, pathogenesis, clinical and pathological features, diagnosis and treatment of this disorder. The baby （male） , with gestational age of 36 weeks and birth weight 4 200 g, was delivered by caesarean section. It presented with hypoglycemia immediately after birth （0.8 mmol/L）. Through the course of the disease, the baby＇s blood sugar manifested with 1.2-2.8 mmol/L although glucocorticoid was administered. 10% glucose solutions were intravenously infused at a speed of 10-17 mg/（ kg · min） for this patient to retain a stable blood sugar level. The plasma insulin level was 24.13 U/L and blood sugar level was 1.5 mmol/L on day 30 of his life. The ratio of plasma insulin （U/L） and plasma glucose （mg/dL） was 0.89. These results suggest an inappropriate insulin secretion resulting in persistent hypoglycemia in this baby and so it was definitely diagnosed with congenital hyperinsulinism.
出处
《中国当代儿科杂志》
CAS
CSCD
2006年第5期391-394,共4页
Chinese Journal of Contemporary Pediatrics
关键词
先天性高胰岛素血症
低血糖
持续性
婴儿
新生
Congenital hypefinsulinism
Hypoglycemia
Persistence
Infant, newborn
