摘要
杆状病毒感染过程中,可能会诱导产生一条导致细胞凋亡的路径,细胞凋亡是一种程序性细胞死亡。宿主细胞的凋亡可以导致细胞的提前死亡或感染的终止,因此细胞凋亡可以限制病毒在被感染机体中的扩散或限制感染机体的发病。家蚕的杆状病毒拥有两种对抗细胞凋亡死亡的基因,p35和iap(inhibitorofapoptosis),它们可能通过阻止病毒感染引起的细胞凋亡或存在于大量生物体内的各种诱导信号引起的细胞凋亡。
During infection, viruses may provoke a cellular pathway leading to apoptosis, a form of programmed cell death. An apoptotic response by the host cell can result in premature cell death or abortive infection, thereby limiting the spread and/or pathogenesis of infection in the organism. Baculoviruses of silkworm also possess two classes of antiapoptotic genes, p35 and iap, which may block apoptosis induced by virus infection or by a variety of induction signals in a phylogenetically broad range of organisms.
出处
《细胞生物学杂志》
CSCD
2006年第5期676-680,共5页
Chinese Journal of Cell Biology
基金
国家自然科学基金资助项目(No.30070579)~~
