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以埃索美拉唑和奥美拉唑为基础的三联疗法根除幽门螺杆菌疗效的荟萃分析 被引量:5

A Meta Analysis of Efficacy of Esomeprazole and Omeprazole in Eradicating Helicobacter pylori in Patients with or without Duodenal Ulcer
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摘要 目的 对以埃索美拉唑和奥美拉唑为基础的1周三联疗法根治幽门螺杆菌的疗效进行系统性分析。方法 联机检索从Medline数据库(2000年—2005年)、维普(2000—2005年)、万方数据库(2000—2005年)中检索埃索美拉唑与奥美拉唑为基础的三联疗法对根治幽门螺杆菌疗效的随机对照临床试验。对各项研究中疗效的比值比(OR)进行荟萃分析,采用Mantel-Haesul方法。结果 共有7项研究符合入选标准。荟萃结果表明以埃索美拉唑为基础的1周标准三联疗法对幽门螺杆菌的根治疗效和以奥美拉唑为基础的标准三联疗法疗效相似[OR(95%CI):1.2746(0.8835,1.8388)]。结论 埃索美拉唑作为奥美拉唑的光学异构体,以其为基础的1周三联疗法能有效地根治幽门螺杆菌,疗效相似于奥美拉唑。 Objective To evaluate the efficacy of one week triple therapy based on esomeprazole or omeprazole in eradicating helicohacter pylori (Hp). Methods Medline date base ( 2000 ~ 2005 ) , vipbrowser data base ( 2000 ~ 2005 ) and wanfang database on line ( 2000 ~ 2005 ) were searched to retrieve randomized controlled trials comparing esomeprazole with other treatments to omeprazole with the others in eradicating Hp. Outcome measure was odds ratio(OR) of eradication of Hp mantel - Haeszel method was used in this analysis. Results seven trials were identified. The results of meta- analysis indicated that one week triple therapy based on esomeprazole had the same effect on eradication of Hp as omeprazole[ OR(95% CI) .1. 2746(0. 8835,1. 8388) 1. Conclusion esomeprazole,the S - isomer of omeprazole,has the same effect on eradicating Hp as omeprazole.
出处 《临床消化病杂志》 2006年第5期286-288,共3页 Chinese Journal of Clinical Gastroenterology
关键词 埃索美拉唑 奥美拉唑 幽门螺杆菌 疗效 荟萃分析 Esomeprazole Omeprazole Helicobacter pylori Efficacy Meta analysis
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共引文献51

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