摘要
目的探讨血清Ⅳ型胶原(Ⅳ-C)在诊断糖尿病早期肾损害的临床价值。方法应用放射免疫法检测52例2型糖尿病(DM)病人及46例正常对照组血清中Ⅳ-C水平。根据尿蛋白含量不同将52例DM病人分为3组。结果52例DM病人血清中Ⅳ-C水平高于正常对照组(P<0·01),DM各组中血清Ⅳ-C水平随尿蛋白含量增加而增加(r=0·95,P<0·01)。DM各组中血中尿素氮(BUN)、肌酐(Cr)升高不明显,但血中Ⅳ-C升高显著,Ⅳ-C与BUN、Cr呈正相关(BUNr=0·76,Crr=0·70,P均<0·01)。结论通过对糖尿病早期肾损害病人血中Ⅳ-C水平与血BUN、Cr、尿蛋白检测结果比较,来判断DM早期肾损害或肾小球纤维化程度有用指标,同时对DM肾脏损害早期诊断及发生发展具有重要的临床价值。
Objective To discuss the clinical value of Type Ⅳ collagen （Ⅳ-C） in blood serum in diagnosing diabetes harm to kidney in early period.Method The Ⅳ-C levels in blood serum of 52 Type-2 diabetes sufferers and 46 people from the normal contrast group were tested by through radiant immunotherapy.52 patients were divided into three groups according their albumen in urine, Group DM1 20 patients, Group DM2 17 patients and Group DM3 15 patients. Result The blood serum Ⅳ-C of the 52 patients was obviously higher than that of the nor-mal Contrast Group, and there was obvious difference （P 〈 0.01）. Besides, the blood serum Ⅳ-C level of the patients of the DM groups enhanced with the increases of their urine albumin. Through relevant urine albumin and blood serum Ⅳ-C analysis, it was showed they were evidently related to each other（r = 0.95, P 〈 0.01）. When the albumin was determined as negative in test of kidney harm of diabetes in early period, the Ⅳ- C level had increased obviously. At the same time, enhances of BUN and Cr of the DM groups were not obvious, but the enhances of Ⅳ-C in blood were evident. The relevant paraaleters r were 0. 76 Ⅳ-C and BUN （ P 〈 0.01）, and r were 0. 70 between Ⅳ- C and Cr （ p 〈 0. 01）. Conclusion Comparison of test results of Ⅳ-C level in blood and BUN, Cr and urine albumin of the patients who suffer from early period kidney harm from diabetes can be the useful indexes of early period kidney harm of diabetes or fiberization degree of renal glomerulus,and at the sane time, it has important clinical value to early diagnosis of diabetes＇ ＇harm to kidney and its occurrence and development.
出处
《广西医学》
CAS
2006年第9期1360-1362,共3页
Guangxi Medical Journal
