摘要
报道新型强心药咪苯甲嗪酮(CI-930)合成。参考有关文献采用了新路线并改进了一些反应的条件和方法,使操作简便合理,收率有所提高。药理实验结果表明它具有明显的抗血栓作用,并选择性抑制血栓素A_2的合成。对开发新的血栓素合成酶抑制剂和防治血栓栓塞性脑心血管疾病具有较重要的理论意义和应用价值。
A novel cardiotonic CJ-930 was successfully designed and synthesized with a new synthetic route. The method and reactive condition on acylating, hydrolytic and condensating reaction were also improved.In addition to convenience of operation, a new synthetic route showed also the advantage over Sircar's method on the raising of total yield 26% to 36%.This compound significantly inhibited the in vitro aggregation of rabbit platelet induced by arachidonic acid, U46619, collagen, ADP and platelet activating factor(PAF). In rabbit or rat platelet, CI-930 depressed the synthesis of thromboxane A.
出处
《第二军医大学学报》
CAS
CSCD
北大核心
1990年第2期114-117,共4页
Academic Journal of Second Military Medical University
基金
国家自然科学基金(编号 3880741)
关键词
咪苯甲嗪酮
合成
抗血栓作用
CI-930
synthesis
phase transfer reaction
antithrombotic effect
