摘要
目的：对比观察补肾方剂八味地黄汤、化瘀方剂丹坤方及补肾化瘀方剂八味丹坤方的延缓衰老作用。方法：老年小鼠灌胃给药，选用自由基代谢为指标。结果：八味地黄汤及丹坤方均能明显改善老年小鼠的自由基代谢。补肾化瘀八味丹坤方的作用明显优于单纯补肾的八味地黄汤或单纯化瘀的丹坤方。结论：补肾化瘀法是更为有效的延缓衰手段，并为衰老的“正虚挟瘀”观点提供了实验证据。
Objective:Comparison of the effect of Baweidihuang Tang Dankun Fang and Baweidankun Fang decoction on the metebolism of free radical in old mice. Methods:Inspect the content of MDA of liver and brain,SOD,CAT and GSH-Px activity in RBC,content of NPSH of liver. Results:The activi-ty of anti-oxidation enzymes of Baweidihuang Tang and Dankun Fang groups markly increased,contents of MDA decreased.Bawei Dankun Fang decoction,the recipe of tonifying kidney-activating blood sta-sis,improved the free radical metabolism of old mice more evidently than that of the others.Conclu-ion:Tonifying kidney-activating blood stasis may be the more effective method on anti-aging.This re-sult is one of the powerful experimental provement for the hypothesis of″Zheng Deficiency Complicated with Staganation″of aging.
出处
《北京医科大学学报》
CSCD
1996年第6期432-433,共2页
Journal of Peking University(Health Sciences)
基金
国家自然科学基金
关键词
衰老
药理学
八味地黄汤
丹坤方
八味丹坤方
Aging/drug eff
Kidney-reinforcing drugs/pharmacal
Free radicals/metab
Blood act sta sis remove drugs/pharmacol
