摘要
目的：配制氧氟沙星漱口液,并考察其稳定性。方法：通过参考有关资料确定处方、制备方法,并采用紫外分光光度法测定其氧氟沙星含量,采用初均速法考察其稳定性。结果：初均速法考察稳定性,线性关系良好,预测其室温有效期为t_(0．9)=310d。氧氟沙星回收率为99．6%,RSD=2．0%(n=5)。结论：该制剂稳定性良好,可作为临床辅助治疗药物。
Objective： To prepare ofloxacin gargle and observe its stability. Methods： Referring to relative literature, the formula and preparing procedure of ofloxacin gargle were established, the stability of the gargle was observed by using initial average rate method. Results： The linear relationship was good in the initial average rate method. The expective effective time at room temperature （t0.9 ） was was more than 310 days. Ofloxacin＇s recycle rate was 99.6%. Conclusion： The preparation has good stability ,and can be used as clinical therapeutic medicine.
出处
《药学实践杂志》
CAS
2006年第5期285-288,共4页
Journal of Pharmaceutical Practice
