摘要
研究丙肝患者血清leptin水平的变化。采用RIA检测65例丙肝组患者,80名对照组血清leptin水平,以及各种生化指标,比较各组的leptin水平以及leptin与各生化指标的相关性。结果显示慢性丙肝患者血清leptin水平较对照组明显升高(P<0.01);血清leptin水平与谷丙转氨酶(ALT)、谷草转氨酶(AST)呈显著性正相关(P<0.05);而与血糖(Glu)、总胆固醇(TC)无明显相关性(P>0.05)。慢性丙肝患者血清leptin水平升高且与肝脏炎症病变严重程度有关,leptin可以作为一个判断肝脏炎症严重程度的指标。
To evaluate changes of serum leptin levels in patients with viral hepatitis C（HCV）, serum leptin levels were determined by RIA in 65 patients with viral chronic hepatitis C and in 80 control subjects ,liver function （ALT , AST） , glucose （Glu） , and total cholesterol （TC） were evaluated too . Campared with controls, the levels of serum leptin were significantly increased in patients with HCV （P〈0.01）. Serum leptin levels had remarkable positive correlations with ALT and AST（P〈0.05）, but not with Glu and TC （P〉0.05）. The levels of serum leptin increased in patients with HCV , which correlates positively with the severity of liver inflammation , so that leptin can be regarded as an index which reflects the severity of liver inflammation .
出处
《标记免疫分析与临床》
CAS
2006年第3期129-130,140,共3页
Labeled Immunoassays and Clinical Medicine
