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肿瘤坏死因子在猴急性胰腺炎中的作用及生长抑素的治疗效果 被引量:8

EFFECT OF TUMOR NECROSIS FACTOR ON ACUTE NECROTIZING PANCREATITIS OF MONKEYS AND THERAPEUTIC EFFECT OF STILAMIN
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摘要 作者采用猴制作急性坏死性胰腺炎(ANP)模型,观察肿瘤坏死因子(TNF)以及生长抑素对猴ANP血浆TNF和猴死亡情况的影响。结果发现:猴ANP早期其血浆TNF明显升高,与猴死亡呈平行关系;生长抑素可明显降低TNF含量,使猴死亡率下降,存活时间延长。提示TNF是ANP早期的重要炎症介质,生长抑素可明显抑制炎症反应过程,对猴ANP有确切的治疗效果。 In the early stage of acute necrotizing pancreatitis (ANP) of experimental monkeys,the concentration of tumor necrosis factor(TNF) in blood was significantly increased. Stilamin could significantly reduce the level of TNF,decrease the mortality,and prolong the survival time of monkeys. The authors draw the conclusion that TNF is an important inflammatory media in the early stage of ANP. Stilamin can significantly inhibit the inflammatory process and has good effect in the treatment of ANP in experimental monkeys.
出处 《普外基础与临床杂志》 1996年第1期4-6,共3页
关键词 疾病模型 肿瘤坏死因子 胰腺炎 生长抑素 Monkey Tumor necrosis factor Acute necrotizing pancreatitis Stilamin
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