摘要
As an important constituent of Glycyrrhiza uralensis Fisch.,glycyrrhetinic acid has been widely used in Chinese traditional medicine.In order to improve its water solubility and bio-avalability and to reduce its side effects,a new derivative of glycyrrhetinic acid,arginine glycyrrhetinate,was synthesized by the reaction of 18β-glycyrrhetinic acid with L-arginine.The chemical composition and structure of this new compound were determined by a series of spectral technology,including MS,NMR,UV and IR spectroscopy.This study will be useful to identification of compounds with similar structure and also be helpful to quality control during drug production.
As an important constituent of Glycyrrhiza uralensis Fisch. , glycyrrhetinic acid has been widely used in Chinese traditional medicine. In order to improve its water solubility and bio - avalability and to reduce its side effects, a new derivative of glycyrrhetinic acid, arginine glycyrrhetinate, was synthesized by the reaction of 18β - glycyrrhetinic acid with L - arginine. The chemical composition and structure of this new compound were determined by a series of spectral technology, including MS, NMR, UV and IR spectroscopy. This study will be useful to identification of compounds with similar structure and also be helpful to quality control during drug production.
出处
《化学研究与应用》
CAS
CSCD
北大核心
2006年第10期1214-1216,共3页
Chemical Research and Application
关键词
甘草次酸精氨酸盐
合成
波谱特征
Arginine glycyrrhetinate
synthesis
spectral technology
characterization
