摘要
蛋白酪氨酸磷酸酯酶1B(protein tyrosine phosphatase 1B,PTP1B)是典型的非受体型PTPase家族的成员之一。PTP1B在胰岛素信号通路中起着重要的负调控作用,是治疗糖尿病和肥胖症的新靶点。寻找PTP1B的特异性抑制剂,通过抑制PTP1B的活性来提高胰岛素信号通路的敏感性,对糖尿病和肥胖症治疗有着重要的应用前景。
Protein tyrosine phosphatase 1 B （PTP1B） is a typical member of non-receptor PTP family. PTP1B plays an important role in the negative regulation of insulin signaling pathway. It has been proved to be a novel target for diabetes and obesity. Inhibition of PTP1B＇s activity could improve the sensitivity of insulin signaling. The discovery of highly effective inhibitors of PTP1B has a promising application in diabetes and obesity therapy.
出处
《生命科学》
CSCD
2006年第5期462-466,共5页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金
青年科学基金项目
