摘要
[目的]探讨错配修复蛋白(hMSH2)及增殖细胞核抗原PCNA异常表达在宫颈癌发病中的意义。[方法]免疫组织化学SP法检测67例宫颈癌和22例非癌子宫颈上皮组织hMSH2与PCNA的表达情况。[结果]宫颈癌组hMSH2阳性表达率为55.20%(37/67),高于非癌上皮组的27.30%(6/22)(P<0.05);宫颈癌组PCNA阳性表达率为73.10%(49/67),高于非癌上皮组的59.10%(13/22),但差异不显著(P>0.05)。宫颈癌hMSH2表达阳性组的PCNA阳性表达率为83.30%(31/37),高于hMSH2表达阴性组的60.00%(12/30)(P<0.05)。[结论]错配修复蛋白(hMSH2)与增殖细胞核抗原PCNA相互影响共同参与宫颈癌的发生。
[Objective] To study the significance of abnormal expressions of DNA mismatch repair protein (hMSH2) and proliferating cell nuclear antigen (PCNA) in cervical carcinogenesis. [Methods] Immunohistochemistry SP method was used to detect the expressions of hMSH2 and PCNA in 67 cervical carcinomas and 22 cervical non - carcinoma eptheis. [Results] The positive expression rate of hMSH2 in cervical carcinoma group being 55.20% was higher than that in cervical non - carcinoma epithchiam group being 27.3% (P 〈 0.05); the positive expression rates of PCNA in cervical carcinoma group and cervical non - carcinoma epithcham group were 73.10% and 59.10% (P 〉 0.05); the positive expression rate of PCNA of cervical carcinoma with the hMSH2 expression being 83.30% was higher than that without the h MSH2 expression being 60.00% (P 〈 0.05). [Conclusion] Interaction between mismatch repair protein (hMSH2) and proliferating cell nuclear antigen PCNA may contribute to carcinogenesis of cervical carcinoma.
出处
《大连医科大学学报》
CAS
2006年第5期373-375,共3页
Journal of Dalian Medical University