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医用磷酸钙骨水泥的制备及性能的实验研究 被引量:1

Preparation and Properties of Medical Calcium Phosphate Cement
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摘要 探索了磷酸四钙(Ca4(PO4)2O,TTCP)的制备,并合成了磷酸钙骨水泥(CPC),对CPC固化时间、引起浸泡液pH值的变化、抗压强度、产物物相组成及微观结构进行了研究。结果表明:在真空条件下、1500℃下煅烧6h可制得TTCP,并含有少量CaO。CPC初凝时间为4min、终凝时间为15min,浸泡1d和7d后的抗压强度分别为20MPa和35MPa,浸泡液的pH值在6.4~8.9之间变化,这些性能均符合临床用CPC的性能要求。CPC水化产物为片状或针状羟基磷灰石(Ca5(PO4)3OH,HA),相互交错呈连续分布的网状结构,这种结构有利于材料强度的提高。实验研制的CPC材料可用于骨缺损的修复治疗。 The preparation of tetracalcium phosphate (Ca4(PO4)2O, TTCP)was studied. Then calcium phosphate cement (CPC)was prepared. The setting time, pH value, compressive strength, X-ray diffraction (XRD) and scanning electron microscope (SEM) analysis of CPC were studied. The results show that TTCP containing small amount of CaO can be successfully attained heated at 1 500℃ for 6 h in vacuum condition. The initial setting time and final setting time of CPC is 4 min and 15 min, respectively. Its compressive strength is 20 MPa after 1-day immersion and 35 MPa after 7-day immersion. The pH value of the solution changes between 6.4 and 8.9. These properties can satisfy the clinical requirements of CPC. The final product of CPC is flake-like or needle-like hydroxyapatite (Cas(PO4)3OH, HA). The continuous network structure of HA appears in the microstructure, this leads to increase the strength of the material. This CPC can be used as bone substitute material.
出处 《生物医学工程学杂志》 EI CAS CSCD 北大核心 2006年第5期1048-1051,共4页 Journal of Biomedical Engineering
基金 国家自然科学基金主任基金资助项目(30370412) 湖南省自然科学基金资助项目(03JJY3027)
关键词 磷酸钙骨水泥 磷酸四钙 制备 固化时间 抗压强度 Calcium phosphate cements (CPC) Tetracalcium phosphate (TTCP) Preparation Setting time Compressive strength
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参考文献12

  • 1周馨,郑昌琼,王方瑚,冉均国.骨水泥及磷酸钙生物活性骨水泥[J].硅酸盐通报,1998,17(5):33-38. 被引量:17
  • 2Brown WE, Chow LC. A new calcium phosphate, watersetting cement. In: Brown PW, ed. Cements Research Progress. Westerville, Ohio: American Ceramic Society,1986:352-379
  • 3Chow LC. Development of setting calcium phosphate cements.J Ceram Soc Jap,1991 ;99(10) : 954
  • 4Komath M, Varma HK. Development of a fully injectable calcium phosphate cement for orthopedic and dental applications. Bull Mater Scl, 2003;26(4): 415
  • 5Driessens FCM, Bohong MG, Bermudes O, et al. Effective formulation for the preparation of calcium phosphate bone cements. J Mater Sci:Mater in Med,1994;5(3) : 164
  • 6Takagi S, Chow LC, Ishikawa K, et al. Formation of hydroxyapatite in new calcium phosphate cements.Biomaterials,1998;19(17): 1593
  • 7Driessens FCM, Boltong MG, de Maeyer EAP, et al. The Ca/ P range of nanoapatite calcium phosphate cements.Biomaterials,2002;32(19): 4011
  • 8Miyamoto Y, Ishikawa K, Fukao H, et al. In vivo setting behaviour of fast-setting calcium phosphate cement.Biomaterials,1995;16(11) : 855
  • 9Miyamoto Y, Ishikawa K, Takechi M, et al. Non-decay type fast-setting calcium phosphate cement: setting behaviour incalf serum and its tissue response. Biomaterials, 1996 ; 17 (14) : 1429
  • 10Driessens FCM, Boltong MG, Bermudez O, et al.Formulation and setting times of some calcium orthophosphate cements:a pilot study. J Mater Sci :Mater in Med, 1993;4 (5) :503

二级参考文献4

  • 1郑昌琼,’96中国材料研讨会96C-MRS论文集,1996年
  • 2刘成安,人工关节的基础与临床研究K戴克成,1993年,7页
  • 3王善沅,生物医学工程学通报,1992年,4卷,1期,124页
  • 4Li Yubao,Hydrolysis and Phase Transition of Alpha TricalciumPhos

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同被引文献17

  • 1陈华,陶笙,张伯勋,马建明.硫酸钙作为骨填充修复材料的新观点与新认识[J].中国临床康复,2005,9(18):180-181. 被引量:11
  • 2张民,王建生,卫小春,杜靖远.可注射性硫酸钙/羟基磷灰石骨替代材料的性能研究[J].中国康复,2006,21(1):16-17. 被引量:6
  • 3Lazary A,Balia B,Kosa JP, et al. Effect of gypsum on proliferation and differentiation of MC3T3-E1 mouse osteoblastic cel!s[J]. Biomaterials, 2007, 28(3): 393-399.
  • 4Mostaed E,Hashempour M, Fabrizi A, et al. Microstructure, texture evolution, mechanical properties and corrosion behavior of ECAP processed ZK60 magnesium alloy for biodegradable applications!J]? J Mech Behav Biomed Mater, 2014, 37; 307-322.
  • 5Zhiguang H,Jiang C. Effect of sodium carbonate solution on self-setting properties of tricalcium silicate bone cement[J]. J Biomater Appl, 2008, 23(3): 247-262.
  • 6Hu NM, Chen Z, Liu X,et al. Mechanical properties and in vitro bioactivity of injectable and self-setting calcium sul- fate/nano-HA/collagen bone graft substitute [J]. J Mech Behav Biomed Mater, 2012, 12: 119-128.
  • 7Chen Z, Liu H, Liu X, et al. Improved workability of injectable calcium sulfate bone cement by regulation of self-setting properties[J]. Mat Sci Eng C-Mater, 2013, 33(3): 1048-1053.
  • 8Thomas MV, Puleo DA, Al-Sabbagh M. Calcium sulfate: a review [J]. J Long Term Eff Med Implants, 2005, 15 (6): 599-607.
  • 9Yaszemski MJ,Payne RG,Hayes WC,et al. In vitro degradation of a poly(propylene fumarate)-based composite mate- rial[J]. Biomaterials, 1996, 17(22): 2127-2130.
  • 10Pan YK, Chen CZ, Wang DG, et al. Microstructure and biological properties of micro-arc oxidation coatings on ZK60 magnesium alloy [J]. J Biomed Mater Res B Appl Biomater,2012, 100(6): 1574-1586.

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