摘要
目的探讨18F-FDGPET双时相显像在鉴别良、恶性病变中的临床价值。方法对28例原发性肺癌、18例消化系恶性肿瘤、13例其他恶性肿瘤和37例良性病变患者于静脉注射18F-FDG185~370MBq后45min和2.5~3h分别进行早期和延迟双时相PET/CT显像,并对重建后的图像进行定性与定量评价,获得病灶区不同时相的平均SUV(SUVmean)和最大SUV(SUVmax),并以延迟显像SUV值的变化大于10%判断为增高或减低。结果在肺癌组28例中,早期显像24例SUV明显增高(85.7%),延迟显像除1例SUV值无变化外,其余均有不同程度增高,4例早期显像结节处为可疑阳性(SUVmax为1.5~2.1)者,延迟显像3例明显增高,1例SUV未见明显增加,延迟显像阳性率为96.4%;消化系统恶性肿瘤18例,其中17例早期SUV升高(94.4%),1例为阴性,延迟显像18例均增高;其他肿瘤13例,早期均为阳性,延迟显像SUV进一步增高。37例良性病变早期有12例SUV增高(>2.5),延迟显像4例仍为阳性。本文病例早期显像总的的敏感性、特异性、准确性、阳性预测值和阴性预测值分别为91.5%、67.6%、82.3%、68.4%和83.3%;延迟显像分别为98.3%、86.5%、93.8%、92.1%和97.0%。结论18F-FDGPET双时相显像对于鉴别肿瘤的良、恶性有一定价值,几乎所有的早期显像为阳性的恶性肿瘤,延迟显像有进一步摄取增高,但部分良性病灶也具有相同特征。
Objective To assess the clinical value of dual-time point ^18F-FDG PET imaging for differentiating malignant from benign lesions. Methods Twenty-eight patients with primary lung cancer, 18 patients with digestive system carcinoma, 13 patients with other kind of malignant tumors, and 37 patients with benign lesions underwent PET-CT at 2 time points： scan 1 at 45 min and scan 2 at 150-180 min after the intravenous injection of 185-370 MBq ^18 F-FDG. Reconstructed images were evaluated qualitatively and quantitatively. The maximum standardized uptake value （SUVmax） and average SUV （SUV ） within the lesions were calculated for both time points. By adopting a SUV change 〉10% between the first and second scans was as a criterion for increase and decrease. Results Twenty-four of 28 primary lung cancers had SUV〉 2.5 at scan 1. Among them, 23 showed increase uptake and the other one showed no change of SUV in the delayed imaging （scan 2）. The other 4 primary lung tumors had SUVs between 1.5 and 2.5 at scan 1 which showed suspected positive, three of whose SUVs increased at time point 2. Seventeen of 18 malignant lesions in digestive system showed SUV〉2.5, the other one showed negative at scan 1, and all showed increase in SUV at scan 2. Of 13 other kinds of tumors, all had SUV〉2.5 at scan 1 and SUVs increased at time point 2. For the benign lesions, 12 showed positive at early and 4 positive in delayed images. The sensitivity, specificity, accuracy, positive and negative predicted value for the early and delayed imaging were 91.5%, 67.6%, 82.3%, 68.4% and 83.3% and 98.3%, 86.5%, 93.8%, 92.1% and 97.0%, respectively. Conclusion These data showed that dual time imaging appeared to be helpful for differentiating benign lesions from malignant lesions. Almost all malignant tumors had SUV〉2.5 at scan 1 and showed further increase at scan 2, but some benign lesions also had this kind of character.
出处
《中国医学影像技术》
CSCD
北大核心
2006年第9期1415-1417,共3页
Chinese Journal of Medical Imaging Technology
