摘要
目的:探讨贲门癌患者根治术治疗前后血清可溶性上皮型钙黏蛋白(SE-CAD)和癌胚抗原(CEA)水平的变化。方法:用化学发光标记免疫法测定36例贲门癌患者血清CEA含量,酶联法测定SE-CAD含量,并与35名正常健康人作比较。结果:贲门癌患者在手术治疗前血清SE-CAD、CEA水平非常显著地高于正常人组水平(P<0.01),手术治疗后6个月复发者血清SE-CAD、CEA水平持续异常,未复发者血清SE-CAD、CEA水平恢复正常。结论:血清SE-CAD和CEA水平的变化与贲门癌患者的病情和预后密切相关,有一定的临床实用价值。
Objective To investigate the changes of serum SE - CAD and CEA levels after definitive surgery in patients with cardiac cancer. Methods Serum CEA levels were determined with CLIA and SE - CAD levels with ELISA in 36 patients both before and after surgery as well as in 35 controls. Six months after surgery, the levels were measured again. Results Before treatment. Serum CEA and SE - CAD level were significantly higher in the patients than those in controls （P 〈 0.01）. Twenty - four of the patients were free from recurrence at 6 months and their serum CEA and SE - CAD levels dropped to within normal range. However, in the 6 patients with recurrence, serum levels of CEA and SE - CAD returned to abnormally high levels. Conclusion Serum CEA, SE - CAD levels were closely related to the disease process of cardiac cancer and were of prognostic values.
出处
《放射免疫学杂志》
CAS
2006年第5期433-434,共2页
Journal of Radioimmanology
关键词
贲门癌
癌胚抗原
可溶性上皮钙黏蛋白
cardiac cancer, carinoembryonic antigen （CEA）, soluble epicyte cadherin （SE - CAD）
