摘要
目的探讨雾化吸入运德素对呼吸道合胞病毒(RSV)感染诱发的小儿哮喘的治疗作用以及对患儿免疫状态的影响。方法RSV感染小儿哮喘67例,随机分为运德素雾化吸入治疗组(运德素组)37例,对照组30例,观察治疗后的临床疗效和免疫功能的变化。结果与对照组比较,运德素组咳嗽、呼吸困难和肺部喘鸣音三种症状的缓解时间均明显缩短(均P<0.01);治疗7天后,运德素组血清IgE降低(P<0.01)、IL-4减少(P<0.01),内源性IFN-α-1b升高(P<0.01),IgG、IgA、IgM水平无显著变化。结论运德素雾化吸入治疗能有效改善RSV感染诱发的小儿哮喘患儿的免疫状态,疗效显著。
Objective To investigate the clinical role of interferon （IFN） on children asthma caused by infection of respiratory syncytial virus （RSV） and the immune state of the patients. Methods 67 cases were divided into two groups, 37 cases were in experimental group treated with breathing in IFN, and 30 cases were in control group treated with breathing in virazole. Results Comparing to control group, cough time, breathe difficult time and breather time in experimental group were remarkably shorter after 7 days （P〈0. 01）. The serum levels of IgE and IL-4 were significantly lower （P〈0. 01）, and serum IFN-α-1b was significantly higher （P〈0. 01）. Conclusion The immune state was improved in the children with asthma by breathing in IFN, and the clinical effect was remarkably.
出处
《华中医学杂志》
CAS
2006年第5期362-363,共2页
Central China Medical Journal
关键词
哮喘
运德素
呼吸道合胞病毒
Asthma
Interferon
Respiratory syncytial virus
