摘要
目的：为了增加布洛芬的溶解度，制成了布洛芬L-赖氨酸复合物并考察复合物的动力学稳定性。方法：采用红外光谱及粉末X-射线衍射验证复合物的形成。通过恒温加速实验结合阿累尼乌斯方程考察复合物的稳定性。结果：形成复合物后布洛芬在水中的溶解度明显增加，其溶液浓度可达100mg／mL，最稳定pH范围是6．0～7．0。结论：布洛芬L-赖氨酸复合物在一定条件下，稳定性较好，水溶性增加，为将布洛芬制成各种液体剂型提供了可能。
Objective： The complex of ibuprofen and L-lysine was prepared to increase the solubility of ibuprofen in water and the stability kinetics of the complex was studied. Method： The formation of the complex was confirmed by IR spectrum and powder X-ray diffraction. The stability of the complex was researched by the constant temperature accelerated testing and Arrhenius equation. Results： The solubility of ibuprofen in water was increased after the formation of the complex, and an ibuprofen solution （ 100 mg/mL） was obtained. The optimum pH of the complex was 6.0 - 7.0. Conclusion： The complex has a good stability and solubility in water under suitable conditions. And it has laid a basis for its being made into liquid dosage forms of ibuprofen.
出处
《药学进展》
CAS
2006年第10期460-463,共4页
Progress in Pharmaceutical Sciences
