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^(99m)Tc-HL91乏氧显像探测肿瘤乏氧状态的研究进展

Advances in identifying the hypoxic status of malignant tumors with ^(99m)Tc-HL91 scintigraphy
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摘要 乏氧显像剂99mTc-HL91能选择性地浓集于肿瘤的乏氧组织或细胞中,通过核医学显像探测肿瘤组织的乏氧,能直接提供肿瘤组织乏氧及其乏氧程度和分布的证据,不仅能用于恶性肿瘤的早期诊断,还能动态监测肿瘤组织乏氧状态,为临床诊断和治疗决策提供重要信息。 ^99mTc-HL91 is a hypoxic agent and can be uptaken by hypoxic issues or cells of malignant tumors. It may be able to provide the information directly in detection of hypoxic status of tumors through imaging. It may be used not only in the early diagnosis of malignant tumors, but also in dynamic detection of hypoxic status of tumors. Thus significant information may be obtained for clinical diagnosis and treatment.
作者 苏新辉 吴华
出处 《国际放射医学核医学杂志》 2006年第4期220-222,共3页 International Journal of Radiation Medicine and Nuclear Medicine
关键词 细胞低氧 放射性核素显像 ^99MTC-HL91 Cell hypoxia Radionuclide imaging ^99mTc-HL91
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参考文献10

  • 1Ballinger JR.Imaging hypoxia in tumors.Semin Nucl Med,2001,31(4):321-329.
  • 2Yutani K,Kusuoka H,Fukuchi K,et al.Applicability of ^99mTc-HL91,a putative hypoxic tracer to detection of tumor hypoxia.J Nucl Med,1999,40(5):854-861.
  • 3Cook GJ,Houston S,Berrington SF,et al.Technetium-^99m-labeled HL91 to identify tumor hypoxia:correlation with 18F-FDG.J Nucl Med,1998,39(1):99-103.
  • 4Van De Wiele C,Versijpt J,Dierckx RA,et al.^99mTc labeled HL91 versus computed tomography and biopsy for the visualization of tumor recurrence of squamous head and neck carcinoma.Nucl Med Commun,2001,22(3):269-275.
  • 5冯彦林,谭家驹,杨劼,余丰文,刘德军,贺小红,黄克敏,袁白虹,苏少弟.99mTc-HL91肺部恶性肿瘤乏氧显像的临床研究[J].中国现代医学杂志,2002,12(21):40-41. 被引量:13
  • 6邓波,陈小凤,肖欢.^(99m)Tc-HL91乏氧显像与^(99m)Tc-MIBI亲肿瘤显像诊断肺肿瘤的对比分析[J].中国误诊学杂志,2003,3(12):1795-1797. 被引量:3
  • 7Kinuya S,Yokoyama K,Konishi S,et al.Increased uptake of ^99mTc-HL91 in tumor cells exposed to X-ray radiation.Ann Nucl Med,2000,14(2):139-141.
  • 8李玲,邢力刚,于金明,李国梁,方永存,杨国仁.非小细胞肺癌放疗中^(99)Tc^m-HL91 SPECT乏氧显像研究[J].中华核医学杂志,2005,25(4):222-223. 被引量:5
  • 9Mizumoto K,Qian LW,Zhang L,et al.A nitroimidazole derivative,PR-350,enhances the killing of pancreatic cancer cells exposed to high-dose irradiation under hypoxia.J Radiat Res (Tokyo),2002,43(1):43-51.
  • 10Suzuki T,Nakamura K,Kawase T,et al.Monitoring of response to radiation therapy for human tumor xenografts using ^99mTc-HL91(4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione doixime).Ann Nucl Med,2003,17(2):131-138.

二级参考文献18

  • 1谢新立,赵文增,刘保平,韩星敏,杜晓光,郭鹏德.^(99)Tc^m-HL91肺癌显像的临床应用[J].中华核医学杂志,2003,23(6):359-360. 被引量:30
  • 2Kinuya S, Yokoyama K, Konishi S, et al. Increased uptake of 99TcmHL91 in tumor cells exposed to X-ray radiation. Ann Nucl Med,2000, 14: 139-141.
  • 3Koh WJ, Bergman KS, Rasey JS, et al. Evaluation of oxygenation status during fractionated radiotherapy in human non-small cell lung cancers using 18F-fluoromisonidazole positron emission tomography. Int J Radiat Oncol Biol Phys, 1995, 33: 391-398.
  • 4Baumann M, Appold S, Zimmer J, et al. Radiobiological hypoxia,oxygen tension, interstitial fluid pressure and relative viable tumour area in two human squamous cell carcinomas in nude mice during fractionated radiotherapy. Acta Oncol, 2001, 40: 519-528.
  • 5Lyng H, Sundfor K, Rofstad EK. Changes in tumor oxygen tension during radiotherapy of uterine cervical cancer: relationships to changes in vascular density, cell density, and frequency of mitosis and apoptosis. Int J Radiat Oncol Biol Phys, 2000, 46: 935-946.
  • 6Van de Wiele C, Versijpt J, Dierckx RA, et al. 99Tcm labeled HL91 versus computed tomography and biopsy for the visualization of tumor recurrence of squamous head and neck carcinoma. Nucl Med Commun, 2001,22: 269-275.
  • 7Koumenis C, Alarcon R, Hammond E, et al. Regulation of p53 by hypoxia dissociation of transcriptional repression and apoptosis from p53-dependent transactivition. Mol Cell Biol, 2001,21: 1297-1310.
  • 8Khalkhali I;Cutrone J;Mena I.Technetium-99m-sestamibi scintimammography of breast lesions: clinical and pathological follow-up,1995(10).
  • 9YUTANI K;Kusuoka H;Fukuchi K.Applicability of 99mTc-HL91, a putative hypoxic tracer,to detection of tumor hypoxia,1999(05).
  • 10van de Wiele C;Versijpt J;Dierckx RA.99Tc(m) labelled HL91 versus computed tomography and biopsy for the visuarlization of tumour recurrence of squamous head and neck carcinoma[J],2001(03).

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