摘要
目的探讨葡萄糖转运蛋白1(GLUT1)和血管内皮生长因子(VEGF)在上皮性卵巢恶性肿瘤中的表达、作用以及两者在上皮性卵巢恶性肿瘤发生、发展过程中的关系。方法应用免疫组织化学方法检测GLUT1、VEGF在正常、良性、交界性及恶性上皮性卵巢肿瘤组织中的表达,并结合临床病理资料进行分析。结果GLUT1、VEGF的表达与上皮性卵巢组织性质有关,恶性肿瘤高于交界性、良性和正常组织。同时与临床分期和淋巴结转移有密切的关系。GLUT1与病理分类亦有关系。结论GLUT1、VEGF异常表达在上皮性卵巢癌的发生发展中起重要作用,可促进上皮性卵巢肿瘤细胞的恶性增殖和侵袭转移。GLUT1、VEGF表达强度作为判断上皮性卵巢癌的恶性程度的监测指标,具有临床应用价值,可为治疗提供参考价值。
Objective To study the expression and function relations of glucose transporter-1 （GLUT1）and vascular endothelial growth factor（VEGF）in the development of human epithelial ovarian carcinomas. Methods Immunohistochemistry method（ SP） was used to examine the expression of GLUT1 and VEGF in normal,benign, borderline and malignant epithelial ovarian tumors. Results The expression of GLUT1 and VEGF was related to the character of epithelial ovarian carcinoma, and the expression of GLUT1 and VEGF in epithelial ovarian carcinoma was higher than that in the borderline, benign, epithelial ovarian tumors and normal tissues. At the same time, it had a close relation with TNM stage and lymph node metastasis. GLUT1 was also related to the epithelial ovarian carcinomatous pathological type. Conclusion The abnormal expression of GLUT1 and VEGF plays an important role in the origin and development of epithelial ovarian cancer and it can promote the epithelial ovarian tumor cells＇ malignant multiplication and transportation. The expression of GLUT1 and VEGF can be used as the checkpoint and has practical meaning in clinic and it can provide reference for treatment.
出处
《哈尔滨医科大学学报》
CAS
北大核心
2006年第5期379-381,384,F0004,共5页
Journal of Harbin Medical University
