摘要
目的探讨分化抑制因子(Id)1(Id1)和3(Id3)表达与胃癌细胞分化、增殖、侵袭转移和预后的关系。方法免疫组织化学染色图像分析Id1和Id3在176例胃癌组织中的表达,并行生存率的logrank检验。结果Id1和Id3蛋白表达强度与胃癌患者的性别、年龄、发生部位、肿瘤细胞分化、增殖、侵袭以及术后生存率未见明显相关性(P>0.05);Id1蛋白表达与胃癌淋巴结转移呈负相关(P<0.05);Id3蛋白表达在不同组织起源的胃癌之间差别有统计学意义(P<0.05)。结论Id1在胃癌淋巴结转移的预测中有一定的应用价值;不同组织起源的胃癌Id3呈差异性表达。
Objective To investigate the relation of differentiation inhibitory factor—— Id1 and Id3 expression to differentiation, proliferation, invasion, metastasis and prognosis in gastric carcinomas. Methods By using immunohistochemistry and image analysis, the expression of Id1 and Id3 was detected and survival rate of patients was analyzed in 176 gastric caricinomas. Results The association between the expression of Id1 and Id3 in gastric caricinomas and sex, age, differentiation and proliferation, and survival rate of gastric cancers was not found, but the expression of Id1 and metastasis of lymph nodes was correlated negatively. The expression of Id3 in tubular adenocarcinoma and mucinous adenocarcinoma was differently significant. Conclusion Id1 has a certain value of application in predicting lymph nodes metastasis in gastric cancer, Id3 expressed differently in gastric cancer from different tissue-genesis.
出处
《福建医科大学学报》
2006年第5期440-442,共3页
Journal of Fujian Medical University
基金
福建省自然科学基金资助项目(C0110013)
关键词
胃肿瘤
分化抑制因子
免疫组织化学
stomach neoplasm
differentiation inhibitory factor
immunohistochemistry
