摘要
探讨肝硬化患者血浆LPS,TNF-α和NO水平的变化及其在肝硬化门脉高压血流动力学紊乱中的作用。检测了45例肝硬化患者(其中代偿期、失代偿期分别为22、23例)血浆LPS,TNF-α和NO水平,并对受试者的血液动力学指标(包括心输出量、心脏指数、外周血管阻力和门静脉血流量)进行同步观察。肝硬化失代偿期患者血浆LPS,TNF-α和NO水平明显高于代偿期(P<0．01),三者之间呈正相关(P<0．001);肝硬化失代偿期患者心输出量、心脏指数、门静脉血流量明显高于代偿期患者(P<0．01),外周血管阻力明显低于代偿期患者(P< 0．01);肝硬化患者血浆NO水平与心输出量、心脏指数、门静脉血流量呈显著性正相关(P<0．001),与外周血管阻力呈显著性负相关(P<0．001)。肝硬化患者血浆LPS,TNF-α和NO生成增多,NO在门脉高压形成及血液动力学紊乱中起重要作用。
To ascertain the relationship of nitric oxide levels （NO） , tumor necrosis factor - α（ TNF - α） and endotoxarmia （LPS） , and the role of NO in hemodynamic dysfunction in liver cirrhotic patients. The plasma levels of LPS, TNF - α and NO of 45 cirrhotic patients were measured. Meanwhile, cardiac output （CO） , cardiac index （CI） , systemic vascular resistance （R） and the quantity of blood flow of portal veins （PVF） were determined. The plasma levels of LPS, TNF -α and NO in decompensated cirrhotic patients were higher than those in compensated patients （P 〈 0. 01 ）. There was positivecorrelation between LPS, TNF-α and NO （P 〈：0.01 ）. Higher levels of CO, CI and PVF and lower R were found in decompensated patients （P 〈0. 01 ）. The levels of NO had a positive relationship with CO, CI and PVF, and had a negative relationship with R（P 〈0.01 ）. LPS, TNF-α and NO were overproduced in patients with liver cirrhosis. NO might play an important role in hemodynamic dysfunction.
出处
《临床肝胆病杂志》
CAS
2006年第5期338-340,共3页
Journal of Clinical Hepatology
