摘要
目的:了解微创Muscle-Sparing开胸术(MST)与标准后外侧切口开胸术(SPT)对肺癌患者手术创伤程度的差别。方法:60例患者随机分入SPT组和MST组各30例。对每例患者术前、术后第1、3、7天清晨、空腹抽取静脉血,用ELISA方法测量血清中IL-1β、IL-6、TNF的浓度,应用速率散射比浊法测量超敏C反应蛋白和血清淀粉样蛋白A的浓度。应用SPSS统计软件比较术前、术后两组患者炎性因子和急性反应期蛋白浓度的变化。结果:两组患者术后炎性因子和急性反应期蛋白较术前有明显变化(P<0．05)。IL-1β、TNF变化程度在两个手术组之间没有明显差异(P>0．05)。IL-6的浓度在术后第3天MST组浓度变化较SPT组要低(P<0．05)。超敏C反应蛋白、血清淀粉样蛋白A的浓度在术后第1、3、7天MST组浓度变化均较SPT组要低。结论:微创Muscle-Sparing开胸术相对于传统标准后外侧切口开胸术对机体造成的创伤较小。
Objective： This study aimed to access the changes of pro-inflammatory cytokines and acute-phrase proteins in lung cancer surgery and compare the difference in surgical stress between muscle-sparing thoracotomy （MST） and standard posterolateral thoracotomy （SPT）. Methods：Sixty patients who underwent lobectomy were randomly divided into MST group （n = 30） and SPT group （n = 30）. The blood was collected in the morning on d 1, d 3, and d 7 postoperation. Plasma levels of interleukin-1 （IL-1）β, IL-6, and tumor necrosis factor （TNF） were determined by enzyme linked immunosorbent assay （ELISA）. C-reaction protein （CRP） and serum amyloid A （SAA） levels were measured by immune rate nephelometry method. The statistical difference before and after surgery was analyzed by SPSS software. Results.There were significant difference in plasma levels of pro-inflammatory factors and acute-phase proteins before and after surgery （P〈0. 05）. The difference in IL-1β and TNF was not significant between MST and SPT group （P〉0.05）. The MST group showed lower level of IL-6 on d 3 postoperation and higher levels of CRP and SAA on d 1, d 3, and d 7 postoperation compared with SPT group （P〈0.05）. Conelusion：MST causes less surgical stress less than SPT to the lung cancer patients.
出处
《肿瘤》
CAS
CSCD
北大核心
2006年第10期941-943,共3页
Tumor
