摘要
目的探讨安非他酮对抑郁症的临床疗效及副反应。方法对58例符合CCMD-3抑郁症诊断标准的抑郁症病人应用安非他酮(28例)与文拉法新(30例)进行对照治疗。应用HAMD(汉米尔顿抑郁量表)、TESS(副反应量表)分别评定疗效和副反应。结果安非他酮的总有效率为95.4%,显效率为88.2%。文拉法新组总有效率为90.2%,显效率为80.6%。在治疗的第2周、第6周两组减分率无显著性差异。安非他酮组的副反应发生率少于文拉法新组。结论安非他酮与文拉法新均能有效治疗抑郁症,安非他酮具有较小的副反应。
Objective To investigate the clinical efficacy and the side effects of Bupropion in the treatment of depression. Methods 58 patients who met the Chinese Classification and Diagnostic Criteria for Mental Disorders, the third Edition （CCMD-3） for depression were involved in this study. Bupropion efficacy in the treatment of depression was assessed with HAMD, and the side effects were evaluated with Treatment Emergent Symptom Scale （TESS）. Results The therapeutic efficacy in bupropion group was similar to that in venlafaxine （P〉0.05）. However the side effects of Bupropion are lighter than venlafaxine. Conclusion The results indicate that both Bupropion and venlafaxine are effective in the treatment of depression, but bupropion showed light side effects.
出处
《中国健康心理学杂志》
2006年第6期645-647,共3页
China Journal of Health Psychology
