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内皮素1及其受体与卵巢癌浸润转移研究进展 被引量：1

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摘要 内皮素(ET)在卵巢癌的发生、发展、浸润、转移过程中起着重要作用。研究发现,ET在卵巢癌中起着分泌和旁分泌的作用,通过内皮素受体A(ETA)与表皮生长因子、血管内皮生长因子、环氧合酶等相互作用,促进卵巢癌细胞的有丝分裂和卵巢癌的新生血管的形成,抑制卵巢癌细胞的凋亡,促进卵巢癌细胞的转移;而且ETA特异性受体阻断剂如能够有效地阻断ET-1的上述作用,可抑制肿瘤的发生、发展、浸润、转移。这些作用机制的研究为卵巢癌的治疗提供了新的方法。
作者 陈义松 华克勤
机构地区 复旦大学附属妇产科医院
出处 《国外医学（妇产科学分册）》 2006年第5期333-336,共4页 Foreign Medical Sciences(Obstet Gynecol Fascicle)
关键词 内皮素 内皮素受体 卵巢癌 治疗
分类号 R737.31 [医药卫生—肿瘤]
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参考文献20

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同被引文献9

  • 1许良中,杨文涛.免疫组织化学反应结果的判断标准[J].中国癌症杂志,1996,6(4):229-231. 被引量：1368
  • 2黄文斌,周晓军,孟奎,陈洁宇,张丽华.胃癌组织中间质细胞CD10的表达及其临床意义[J].诊断病理学杂志,2005,12(6):447-449. 被引量：9
  • 3Bagnato A,Salani D,Di Castro V,et al.Expression of endothelin 1 and endothelin A receptor in ovarian carcinoma:evi-dence for an autocrine role in tumor gro-wth[J].Cancer Res,1999,59(3):720-727.
  • 4Sumitomo M,Shen R.Nanus D et al.In-volvement of neutral endopeptidase in ne-oplastic progression[J].Biochim Biophys Aeta,2005,1751(1):52-59.
  • 5Khin EE,Kikkawa F,Ino K,et al.Neutral endopeptidase/CD10 expression in the stroma of epithelial ovarian carcinoma[J].Int J Gynecol Pathol,2003,22(2):175-180.
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  • 7Rosono L,Spinella F,Di castro V,et al.Endothelin-1 promotes epithelial-to-mes enchymal transition in human ovarian cancercells[J].Cancer Res,2005,65(24):1649-657.
  • 8Salani D,Di Castro V,Nicotra MR.et al.Role of endothelin in neovascularization of ovarian carcinoma[J].Am J Pathol,2000,157(5):1537-1547.
  • 9Suzuki T,Kikkawa F,Ino K,et al.Imbal ance between neutral endopeptidase 24.11and endothelin-1 expression in human en dometrial carcinoma[J].Oncology,2001,60(3):258-267.

引证文献1

国外医学（妇产科学分册）
2006年 第5期

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