摘要
目的：探讨c—Src基因在家族性巨颌症中的表达及意义：方法：应用原位杂交方法与免疫组织化学技术检测12例家族性巨颌症病变组织中c—Src蛋白与c—SrcmRNA的表达：结果：12例家族性巨颌症病变组织中的多核巨细胞、10％～15％的单核圆形基质细胞胞浆表达c—Sre蛋白与mRNA，二者阳性细胞表达率无显著性差别，c—SrcmRNA表达结果与c—Src蛋白相一致，二者呈正相关关系：结论：c-Src表达可能与家族性巨颌症病变中多核巨细胞的形成和破骨特性有关：
Objective： To investigate and analyze the expression of c -Src in cherubism and its significance. Methods： Expression of c - Src protein and c - Sre mRNA was respectively detected by immunohistochemistry and by in situ hybridization in 12 cases of cherubism. Results ： The localization of c - Src protein as well as the brown granular reaetion products of c - Src mRNA was diffusely distributed in the cytoplasm of the muhinucleated giant cells and in about 10 - 15% round - shaped mononuclear stromal cells in lesions of 12 cherubism cases. There were no significant differences for positive cells between expression of e - Sre protein and mRNA. The significant correlation was found between the expression of c - Src protein and mRNA. Conclusion ： The expression of c - Src could be associated with osteolytie characteristics of osteoclasts and might relate to the formation of.muhinucleated giant cells in cherubism.
出处
《口腔医学研究》
CAS
CSCD
2006年第5期513-516,共4页
Journal of Oral Science Research
