摘要
目的:了解磷酸钙骨水泥的优良性质,以推动骨骼系统理想药物载体的研究。资料来源:应用计算机检索PUBMED1990-01/2006-01期间的相关文章,检索词为“drugdelivery,calciumphosphatecements,boneregeneration,drugcarriers”,并限定文章语言种类为English。同时计算机检索万方数据库1990-01/2006-01期间的相关文章,检索词为“药物控释,磷酸钙骨水泥,药物载体”,并限定文章语言种类为中文。资料选择:对资料进行初审,并查看每篇文献后的引文。纳入标准:文章所述内容应与磷酸钙骨水泥研究相关。排除标准:重复研究或Meta分析类文章。资料提炼:共收集到32篇相关文献,26篇文献符合纳入标准,排除的6篇文献为内容陈旧或重复。本文选用符合纳入标准的20篇文献,1篇涉及磷酸钙骨水泥的组成和理化特性,5篇涉及磷酸钙骨水泥作为药物载体,3篇涉及磷酸钙骨水泥与药物混合后的理化性质,6篇涉及载药磷酸钙骨水泥的药物释放动力学,4篇涉及磷酸钙骨水泥的体内评价。资料综合:磷酸钙骨水泥是一种自固化、生物陶瓷型骨水泥,具有良好的生物相容性和骨传导性。其大量的微孔结构可以作为多种药物和活细胞的载体,具有不丧失细胞活性或改变药物的特性,且可以通过微创手段将磷酸钙骨水泥注射到目标部位。结论:磷酸钙骨水泥具有良好的生物相容性和骨传导性,有望成为治疗多种骨骼系统疾病理想的药物载体。
OBJECTIVE： To understand the property of calcium phosphate cement （CPC）, so as to contribute to the research on satisfactory drug carriers of skeletal system.
DATA SOURCES： A computer-based search of relevant articles published between January 1999 and January 2006 was conducted in Pubmed with the key words of ＂drug delivery, calcium phosphate cements, bone regeneration, drug carriers＂, and the language was limited to English. Meanwhile, Wanfang database was searched for relevant articles between January 1999 and January 2006 with the key words of ＂drug delivery, calcium phosphate cements, drug carriers＂, and the language was limited to Chinese.
STUDY SELECTION： Data were checked in the first trial, and the quotations at the end of each literature were checked. Inclusion criteria,＂ Articles about CPC. Exclusion criteria： Repetitive studies and Meta analysis.
DATA EXTRACTION： A total of 32 relevant literatures .were collected, and 26 were in accordance with the inclusion criteria. Six old and repetitive articles were excluded. Of 20 enrolled literatures, which were in accordance with the inclusion criteria, one referred to the composition and perfect property of CPC, 5 were about the CPC as drug carriers, 3 were involved in the perfect property of CPC mixed with drug, 6 were in relation to the drug delivery dynamics of CPC and 4 were related to the evaluation of CPC in vivo.
DATA SYNTHESIS： CPC is a kind of self-setting, bioceramics-type cement with favorable biocompatibility and ostcoconductivity, whose cellular structure of large amount can be taken as the carrier of multiple drugs and living. CPC has the properties of maintaining activity of cells and denaturalization. Moreover, CPC can be injected into the targeting part by micro-wounds.
CONCLUSION： CPC has better biocompatibility and ostcoconductivity, which might be a perfect drug carrier in the treatment of a great number of diseases for the musculoskeletal system.
出处
《中国临床康复》
CAS
CSCD
北大核心
2006年第41期117-120,共4页
Chinese Journal of Clinical Rehabilitation
