摘要
目的:探讨不稳定型心绞痛患者抑郁性情绪障碍与T淋巴细胞及血清C反应蛋白的关系。方法:根据Zung抑郁自评量表(SDS)评分将90例不稳定型心绞痛患者分为抑郁组(34例)及对照组(56例),测定T淋巴细胞亚群、T淋巴细胞表达人类白细胞抗原-DR基因(HLA-DR)及血清高敏C反应蛋白(hsCRP)水平。结果:抑郁组CD8、T淋巴细胞表达HLA-DR高于对照组(26.39±6.17vs22.04±6.61,28.08±9.13vs23.86±9.02,均P<0.05),抑郁组CD4/CD8低于对照组(0.42±0.30vs0.62±0.52,P<0.05)。抑郁标准分与CD8呈正相关(P<0.05)。结论:抑郁性情绪障碍影响不稳定型心绞痛患者T淋巴细胞亚群及活性的改变。
Objective： To explore the influence of depression on T-lymphocytes and C-reactive protein of patients with unstable angina. Methods： Ninety patients with unstable angina were divided into the depression group （thirty-four cases） and the control group （fifty-six cases） according to the standard score of depression of Zung Self-Rating Depression Scale （SDS）. The subsets of T-lymphocytes, human leucocyte antigen-DR （HLA-DR） expression with T-lymphocytes and the concentration of high-sensitivity C-reactive protein （hsCRP） in serum were detected. Results： The level of CD8, HLA-DR antigen expression with T-lymphocytes in the depression group were higher than those of the control group （26.39 ± 6.17 vs 22.04±6.61, 28.08 ± 9.13 vs 23.86 ± 9.02 respectively all were P 〈 0.05）. The level of CD4/CD8 in the depression group decreased compared with the control group （0.42 ±0.30 vs 0.62 ± 0.52 P 〈 0.05）. Standard score of depression was positively related with the level of CD8 （P 〈 0.05）. Conclusion： Depression influences the subsets and activity of T-lymphocytes in patients with unstable angina.
出处
《天津医药》
CAS
北大核心
2006年第10期691-693,共3页
Tianjin Medical Journal
基金
天津市卫生局资助课题(项目编号:02KY13)
