摘要
目的静脉联合使用米力农(Mil)与前列腺素E1(PGE1)防治术后右心衰竭,并初步探讨其机制。方法选择体外循环下行心脏畸形矫正的先天性心脏病并肺动脉高压病儿28例,随机分为对照组(I组)、Mil组(II组)、PGE1组(III组)、Mil与PGE1合用组(IV组)。通过Swan-Ganz导管及动脉导管测定各组用药前后血流动力学指标,包括平均肺动脉压力(PAP)、平均主动脉压力(MAP)、心脏指数(CI)、体循环阻力(SVR)和肺循环阻力(PVR),并比较各组呼吸辅助时间及药物的毒副作用。结果与其他3组相比较,IV组用药后的PAP、PVR及SVR下降明显,同时CI显著增加,并缩短了呼吸辅助时间。结论静脉联合应用Mil和PGE1可有效防治术后右心衰的发生。
Objective To study the effect of milrinone（Mil） and prostaglandin E1 （PGE1） on postoperative right ventricular failure（RVF）. Methods 28 patients with congenital heart diseases and pulmonary hypertension tmdergoing cardiopulmonary bypass （CPB） were randomly divided into four groups： control group （group Ⅰ）, receiving Mil （Group Ⅱ）, receiving PGE1 （Group Ⅲ）, and receiving both Mil and PGE1 （group Ⅳ）. The hemodyrmmic indexes of all the patients, including mean pulmonary artery, pressure （PAP）, mean arterial blood pressure （MAP）, cardiac index（CI）, systemic vascular resistance （SVR） and pulmonary vascular resistance（PVR）, were measured and compared. Intubation time and side effects were observed. Results Compared with the other three groups, postoperative PAP,PVR and SVR in group IV deceased and CI increased significantly. The intubation time was also shorter in group IV. Conclusion Postoperative RVF can be treated efficiently by using Mil and PGE1.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
2006年第5期308-310,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
基金
黑龙江省重大科技攻关项目资助(G98L19-2-1)
关键词
心脏缺损
先天性
心室功能障碍
右
手术后并发症
前列地尔
米力农
Heart defects, congenital
Ventricular dysfunction, right
Postoperative complications
Alprostadil Milrinone
