摘要
间质干细胞是存在于骨髓、脐带血、肌肉、骨骼、软骨、脂肪、血管等的多能干细胞。在体外培养时,细胞贴壁生长,呈成纤维样细胞表型,在一定条件下可分化内胚层、中胚层和外胚层细胞。因间质干细胞具有易分离扩增、基因转染、支持体外造血、体内造血重建以及免疫调节作用等特点,在临床上有很大的潜在应用价值。
Mesenchymal stem cell is a kind of muhipotent stem cell that resides in bone marrow ,cord blood, muscle, bone, cartilage, fat, blood vessel and so on. Mesenchymal stem cell cultured in vitro adheres to the wall and diplays the fibro-like phaenotype and differentiates to the cells of endoderm, mesoderm, ectoderm under certain condition. Mesenehymal stem cell has the potential for application because of it＇s characteristics of isolated and amplificated easily,gene transfection, haematopoiesis and immunoregulation. Here we reviewed the advancement of mesenchyma stem cell in immunoregulation.
出处
《国际免疫学杂志》
CAS
2006年第6期345-349,共5页
International Journal of Immunology
基金
国家自然科学基金项目(30471938)
卫生部研究课题(WKJ2005-2-024)
关键词
骨髓
间质干细胞
免疫调节
Bone Marrow
Mesenchymal Stem Cells
Immunoregulation
