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血小板活化因子乙酰水解酶基因多态性与支气管哮喘的相关性 被引量：1

Correlation of Platelet-Activating Factor Acetylhydrolas Gene Polymorphism and Bronchial Asthma in Children
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摘要 目的研究血小板活化因子乙酰水解酶(PAF-AH)基因多态性与支气管哮喘儿童发病的关系。方法采用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)分析技术,对53例哮喘及35例正常对照组儿童PAF-AH第11外显子Ala379Val位点基因多态性进行分析。结果哮喘组患儿基因组型频率和等位基因频率与对照组比较均无显著性差异(P均>0.05)。结论PAF-AH第11外显子Ala379Val基因突变与儿童支气管哮喘发病无关。 Objective To study the correlative association between platelet-activationg factor acctylhydrolase （PAF-AH）genetic polymorphism and bronchial asthma in children.Method Gecetic polymorphism was analyzed in 53 asthmatic children and 35 healthy children with polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）technique.Result There were no significant differences between asthmatic group and nmrmal contral group about distribution frequendy of genotypes and alleles all（P〉0.05）,Conclusion PAF-AH-Ala 379Val gene mutation is unrelated to bronchisl asthma in children.
作者 李海林 程飞 黄永坤
机构地区 昆明医学院第一附属医院儿科
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2006年第20期1396-1397,共2页 Journal of Applied Clinical Pediatrics
关键词 血小板活化因子乙酰水解酶 哮喘 基因 多态性 儿童 聚合酶链反应-限制性片段长度多态性分析 platelet-activating factor acetylhydrolase asthma gene polymorphism child polymerase chain renction-restriction fragment length polymorphism
分类号 R725.6 [医药卫生—儿科]
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实用儿科临床杂志
2006年 第20期

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