摘要
目的 探讨雷米普利对老年高血压病患者胰岛素抵抗的的影响。方法 将128例老年高血压痛患者随机分为雷米普利组64例，硝苯地平组64例，雷米普利组口服雷米普利（商品名瑞泰）2．5～10mg每日1次，硝苯地平片10～20mg每日3次，8周为一疗程。观察治疗前后空腹血糖、餐后2h血糖、空腹胰岛素、餐后2小时胰岛素及胰岛素敏感性指数的变化。结果 两组患者治疗前后空腹血糖性差异无统计学意义（P〉0．05），雷米普利组治疗后餐后2h血糖、空腹胰岛素、餐后2小时胰岛素和胰岛素敏感性指数较治疗前差异有统计学意义（P〈0．05）。硝苯地平组治疗前后各项指标差异无统计学意义（P〉0．05）。结论 雷米普利能显著降低老年高血压病患者餐后2h血糖、提高血胰岛素敏感性指标，从而改善胰岛素抵抗。
Objective To explore the insulin resistance effects of ramipril on old patients with primary hypertension. Methods 128 patients with primary hypertension were divided randomly into ramipril and nifedipine group. The ramipril group（ n =64） were treated with 2, 5 - 10mg ramipril once a day and nifedipine group（ n = 64） with 10 -20mg nifedipine trice a day. Before and after treatment, the blood sugar of fasting and 2 hours after meal, the insulin of fasting and 2 hours after meal and insulin sensitive index were measured. Results Fasting blood sugar in both groups was not significantly different（ P 〉0. 05）before and after treatment. 2h postmeal blood sugar, fasting and 2h postmeal insulin, insulin sensitive index in the ramipril group were significantly differert before and after treatment （ P 〈 0. 05 ）, while the all indexes were not different in the nifedipine group （ P 〉 0. 05 ）. Conclusion Ramipril can decrease 2h postmeal blood sugar of patients with old primary hypertension and increase insulin sensitive index, so as to improve insulin resistance.
出处
《医药论坛杂志》
2006年第19期32-33,35,共3页
Journal of Medical Forum
关键词
雷米普利
高血压病
胰岛素抵抗
Ramipril
Primary hypertension
Insulin resistance
