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载脂蛋白B研究进展 被引量:13

Advances in the Research of Apolipoprotein B
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摘要 载脂蛋白B(apolipoprotein B,ApoB)在脂类代谢、胆固醇的运输中起关键性的作用,其在心血管疾病、家族性β脂蛋白血症、肥胖和胆囊疾病的研究中尤为重要。本文对ApoB独特的基因结构、表达模式及其多态性与疾病关系的研究进展进行了综述。 Apolipoprotein B (ApoB) plays an essential role in metabolism of the lipids and transport of the cholesterol, and is one of the essential factors in the research of the coronary artery disease, familial dysbetalipoproteinemia, obesity, and gallstone disease. The research progress of ApoB gene's peculiar gene structure, expression patterns, and correlation between its polymorphism and diseases are reviewed.
作者 张森 李辉
出处 《国际遗传学杂志》 CAS 2006年第5期364-367,共4页 International Journal of Genetics
基金 国家自然科学基金重点项目(No.30430510) 黑龙江省杰出青年基金项目(No.JC-02-06)
关键词 APOB 基因结构 表达模式 多态性 疾病 ApoB Gene structure Expression patterns Polymorphism Disease
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