摘要
目的:建立用HPLC法测定复方甘草片中吗啡含量的方法。方法:采用硅胶柱,以水-乙腈-甲酸(85∶15∶0.05)为流动相;流速为0.7ml·min-1;检测波长220nm。结果:吗啡在4.148μg·ml-1-37.332μg·ml-1浓度范围内与峰面积呈良好线性关系(r=0.9999),平均回收率为99.6%,RSD=1.75%(n=5)。结论:方法简便,重现性好,可作为本品质量控制方法。
Objective： An HPLC method for determination of Morphine in Compound Liguorie Tablets was established.Method：Using a LC-SI column,the mobile phases consisted of water-acetonitrile-formic acid （85 ： 15 ： 0. 05）. fhe folw rate was 0.7ml · min^-1 and the dectection wavelength is 220nm. Results ：The linear range was 4. 148μg · min^-1 - 37. 332μg· min^-1 ,r= 0. 9999. The mean recovery was 99.6% and RSD was 1.75%（n=5）. Conclusion：The methods is simple and accurate and could be used for quality control of Compound Liguoric Tablets.
出处
《中国药品标准》
CAS
2006年第5期43-45,共3页
Drug Standards of China
