摘要
目的探讨稀土元素镧的慢性暴露对大鼠血糖、血脂的影响。方法分别以0．1、2和40mg／kg剂量的三氯化镧（LaCl3）给大鼠经口灌胃，每天1次，90d后处死；取全血测定糖化血红蛋白（HbAlc），分离血清测定血糖（Glu）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平。结果与对照组相比，3个LaCl3暴露剂量组大鼠HbAlC、血清Glu、TG和LDL-C水平无统计学意义；0．1和2mg／kg剂量LaCl3暴露组大鼠血清TC水平分别为（1．38±0．14）mmol／L和（1．37±0．26）mmol／L，与对照组大鼠（1．57±0．14）mmoL／L相比有明显降低；0．1mg／kg剂量LaCl3暴露组大鼠血清HDL-C为（0．79±0．12）mmol／L，比对照组大鼠（0．93±0．10）mmol／L有明显降低。结论0．1～40mg／kg LaCl3慢性暴露对大鼠血清Glu、TG和LDL-C水平无显著影响；低、中剂量LaCl3慢性暴露可使大鼠血清TC和HDL-C降低。
Objective To explore the effects of serum glucose and lipids by on chronically lanthanum exposure in rat. Methods The Wistar rats were treated with oral exposure dose 0.1, 2 and 40 mg/kg of lanthanum chloride （LaCl3） respectively, after 90 days the rats were sacrificed and the blood was collected for weasuring the glycosylated hemoglobin A （HbAlc）, the serum was used for weasuring glucose, total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C）levels. Results There were no any differences among the control and 3 dose LaCl3 exposed rats on the blood HbAlc and serum Glu, TG and LDL-C levels （P 〉 0.05）. The serum TC in 0.1 and 2 mg/kg LaCl3 dose group rats were （1.38±0.14） mmol/L and （1.37±0.26） mmol/L respectively. It was lower than that of the controls （1.57±0.14） mmol/L significantly （P 〈 0.05）, the serum HDL-C in 0.1 mg/kg dose group rats was （0.79±0.12） mmol/L and obviously lower than that of control group rats （0.93±0.10） mmol/L （P 〈 0.05 ）. Conclusion 0.1 - 40 mg/kg LaCl3 chronically exposed have not greater effect on serum glucose, TG and LDL-C levels in rats, but the lower dose LaCl3 chronical exposure might cause serum TC and HLD-C level decreasing.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
2006年第6期419-421,共3页
Chinese Journal of Preventive Medicine
