摘要
目的:探讨环丙沙星致过敏性休克的特点及相关因素,为临床安全用药提供参考。方法:利用“中文期刊全文数据库”、“中文科技期刊全文数据库”和“万方数据医药信息镜像系统”,对1979年1月至2005年12月发表的文献进行全面检索,检索到环丙沙星致过敏性休克相关文献73篇,患者共81例。对81例患者用药情况进行分类统计和分析总结。结果:81例患者中男性42例(52.5%),女性38例(47.5%),1例性别不详;静脉滴注62例(76.5%),口服19例(23.5%);治愈78例(96.3%),死亡3例(3.7%)。用药后出现休克症状的时间最短为静脉滴注10s左右,最长为连续用药第5天静脉滴注60min左右。有药物过敏史者24例,其中对青霉素过敏者16例;既往无药物过敏史者25例;用药前未询问有无过敏史者32例。1995至2005年每年均有环丙沙星致过敏性休克病例报道,发生地区几乎遍及全国。结论:临床应高度重视环丙沙星引起过敏性休克的严重不良反应,以确保用药安全。
Objective： To discuss the characteristics and related factors of ciprofloxacin-induced anaphylactic shock, and provide reference for clinical safe drug use. Methods： The literature between January 1979 and December 2005 was retrieved from ＂Chinese Journal Full-text Database＂, ＂Chinese Science and Technology Journal Full-text Database＂, and ＂Wanfang Medicine Data China info＂, Eighty-one cases with ciprofloxacin-induced anaphylactic shock of 73 papers were collected and analyzed. Results： Of the 81 cases, 42（52.5%） were male, 38（47.5%） were female, and one case＇ sex was unknown; 62（76.5%） were intravenous infusion, and 19（23.5%） were oral administration; 78（96.3%） were recovered, 3（3.7%） were dead. The time to onsef of anaphylactic shock varied fi＇om l0 seconds after intravenous infusion of ciprofloxacin to 60 minutes in fifth day after successive treatment of intravenous infusion of ciprofloxacin. Of the cases, 24 had allergic history, 25 had no allergic history. The investigation showed that ciprofloxacin-induced anaphylactic shock was not rare, and it was occurred in almost all areas of the whole country from 1975 to 2005. Conclusion： Careful attention should be paid to the serious reaction of ciprofloxacin-induced anaphylactic shock in clinical practice to ensure safe medication use.
出处
《药物不良反应杂志》
2006年第5期346-349,共4页
Adverse Drug Reactions Journal
关键词
环丙沙星
过敏性休克
ciprofloxacin
anaphylactic shock
