摘要
目的观察针刺对乙酸诱发大鼠胃溃疡愈合质量(QOUH)的影响。方法用冰乙酸制备大鼠慢性胃溃疡模型,设正常对照组、模型组、雷尼替丁组、针刺+雷尼替丁组和针刺组,各组大鼠依设计进行相应处理,对各组大鼠愈合性胃溃疡外观表现、病理组织学进行定量观察测定,同时采用放射免疫法测定动物血清中EGF含量。结果各治疗组溃疡愈合状况明显优于模型组;与雷尼替丁组比较,针刺组溃疡面积及炎细胞浸润数量明显减少,再生黏膜厚度及EGF含量显著升高;针刺+雷尼替丁组与针刺组比较溃疡面积及炎细胞浸润数量减少,再生黏膜厚度增加,EGF含量升高但差异无显著性。结论针刺可减少溃疡面积,增加黏膜厚度,减少固有层炎细胞浸润数量,减轻胃黏膜损伤程度,升高血清EGF含量,这可能是促进胃溃疡愈合速度、提高胃溃疡愈合质量、减少溃疡复发的作用机制。
Objective:To research the effect of acupuncture on the quality of ulcer healing (QOUH)in gastric ulcer rats. Methods:Rat model of chrouic gastric ulcer was induced by acetic acid.40 healthy SD rats were divided into the normal control group,the model group,the acupuncture group and the westerns medicine group,the combining acupuncture and the westerns medicine gruop. Except the normal control group, the others rats were treated with 0.9% NaCl, acupuncture, westerns medicines, combining acupuncture and westerns medicines respectively. The changes of contents of epidermal growth factor (EGF) in serum, thickness of regenerated mucosa, number of inflammatory cells and area of gastric mucosa were examinedwas observed quantitatvaly.Results:Condition of ulcer healing of all treatment groups are better than of the model group.Acupuncture can decrease signifently area of gastric mucosa, lesion number of inflammatory cells. The contents of EGF in serum and thickness of regenerated mucosa were siginifcant increased than westerns medicing group, the changes of detecting of combining acupuccture and westerns medicing group are more apparently than singal acupuncture, but level of EGF is no difference from sham- operated. Conclusion:Acupuncture can relieve the stress lesion of gastric mucosa possibly in habiting the lesion of free radical in gastric mucosa, area of gastric mucosa, number of inflammatory cessl and improving EGF in serum, thickness of regenerated mucosa. This is possibly material base for acceleration ulcer healing and improving the quality of ulcer health resulting in preventing from ulcer resurrence.
出处
《中国中医急症》
2006年第11期1259-1260,共2页
Journal of Emergency in Traditional Chinese Medicine
