摘要
目的:就抽动障碍儿童细胞免疫功能的变化、抗核抗体的产生进行了研究,进一步探讨抽动障碍的病因及发病机制。方法:采用病例对照的实验方法,对30例抽动障碍儿童和30例正常儿童实施了血液抗核抗体、T淋巴细胞亚群的实验室检查。结果:病例组CD 3、CD 4、CD 4/CD 8比值显著低于对照组,病例组抗核抗体(ANA)吸光度值显著高于对照组。结论:抽动障碍儿童存在细胞免疫功能紊乱,即细胞免疫功能降低以及病毒或细菌感染后自身抗体(抗核抗体)的产生。发病前感冒等因素都可能是诱发儿童发生抽动障碍的危险因素。
Objective： To study the cellular immune function, anti - ANA （ antinuclear antibody） in children for exploring profoundly its etiology mechanism and providing appropriate measures of clinical intervention. Methods： The case control experimental method were conducted. 30 children with TD and 30 normal children were implemented laboratory check about antinuclear antibody （ANA） , T lymphocyte subsets in blood. Results： The CD 3, CD 4 and helper/suppressor ratio （CIM/CD8） were significantly lower in case group than those in control group, the absorbency of anti - ANA were significantly higher in case group than that in control group. Conclusion ： Children with TD have the abnormity of cellular immune function and the higher concentration of autoantibody. Having a cold recently would be a risky factor resulting in TD.
出处
《中国妇幼保健》
CAS
北大核心
2006年第21期2951-2953,共3页
Maternal and Child Health Care of China
关键词
抽动障碍
儿童
细胞免疫
抗核抗体
危险因素
Tic disorders
Children
Cellular immune function
Antinuclear antibody
Risky factors
