摘要
目的研究我国南方重症肌无力(MG)的临床特点。方法回顾性分析1987-03—2006-01作者医院确诊的1 520例MG患者的病例资料。结果该组MG患者男∶女=1∶1.18,发病年龄在14岁以下者占47.0%,以眼睑下垂为首发症状者占61.25%,按改良Osserman分型Ⅰ型占67.1%,危象发生率为10.86%,MG伴其他自身免疫性疾病的发生率为8.68%,其中甲亢的发生率为6.84%。家族性MG的发生率为1.91%。结论该组病例的临床特点与国外报道差异较大,提示我国MG临床表现有其独特之处,充分认识其临床特点将有助于临床诊断和治疗。
Objective To investigate the clinical features of the patients with myasthenia gravis （MG）. Methods Retrospective analysis on clinical data was held on 1 520 patients who were diagnosed with MG at the first affiliated hospital of Sun Yat-sen University between March 1987 and January 2006. All statistical analyses were performed with the SPSS 13.0 statistical package. Results Among 1 520 patients, there were 698 men and 822 women, and male-to-female ratio was 1 ： 1.18. Seven hundred and fourteen patients （47.0%） were younger than 14 years. Nine hundred and thirty one patients （61.3%） manifested ptosis at onset. According to Osserman classification, 1 020 patients （67.1%） were classified as type Ⅰ. One hundred and sixty five patients （10. 86% of all 1 520 patients） had reported 240 attacks of myasthenic crisis, 14 patients died of crisis, 5 of whom gave up treatment, but none of them died after 1998. The incidence of crisis was higher in patients of type Ⅲ, Ⅳ than that of type Ⅰ, Ⅱ a, Ⅱ b（P〈0.05）. There were 132 patients （8.68%） with MG combined with other autoimmune diseases, in which the incidence of hyperthyroidism was 6. 8 % （104/1 520）. There were 13 families （0. 86 %） whose relatives had other autoimmune diseases. The incidence of family myasthenia gravis was 1.91% （29/1 520）. Conclusions The clinical features in this group are evidently different from those reports from abroad. It suggested that MG in China has its distinct characteristics. The important information of the clinical features available in this study may facilitate the diagnosis and therapy of MG in China.
出处
《中国神经免疫学和神经病学杂志》
CAS
2006年第6期326-330,共5页
Chinese Journal of Neuroimmunology and Neurology
基金
广东省科委重点基金资助项目(102016
133017)
