摘要
以脂肪醛与丙二酸为原料,通过Knoevenagel反应制备了(E)-3-烷烯羧酸,反应以二甲苯为溶剂,在回流条件下进行。考察了哌啶、吡啶及4-二甲氨基吡啶(DMAP)对反应产物的影响。结果表明,采用哌啶催化时,反应产率最高,可达70%左右,(E)-3-烷烯羧酸与副产物α,β-不饱和羧酸的摩尔比可达12/1以上;DMAP作催化剂,产率较低,在60%左右,反应选择性略高于哌啶;吡啶作催化剂时产率最低,反应选择性也最差,(E)-3-烷烯羧酸与副产物α,β-不饱和羧酸的摩尔比只有3/1。
（E）-3-Alkenoic acids （ Ⅰ ） were synthesized by Knoevenagel reactions of aliphatic aldehydes with malonic acid in xylene under reflux. The effect of piperidine, pyridine and 4- dimethylaminopyridine （DMAP） as catalyst on the reaction was investigated. With piperidine as catalyst,yield of the product Ⅰ was the highest, around 70%, and the molar ratio of Ⅰ to the by product, α ,β-unsaturated carboxylic acids （ Ⅱ ） ,was up to 12：1. DMAP gave lower yield （about 60% ） and slightly higher selectivity. Pyridine gave the poorest yield and selectivity that the molar ratio of Ⅰto Ⅱ was only 3：1.
出处
《精细化工》
EI
CAS
CSCD
北大核心
2006年第11期1125-1127,共3页
Fine Chemicals
基金
北京市教育委员会科技发展计划项目(KM200510011007)~~
