摘要
目的观察灵芝孢子油的扶正减毒作用。方法以正常和H22荷瘤小鼠为对象,通过检测外周血WBC数、骨髓有核细胞数、脾脏指数、胸腺指数来观察口服灵芝孢子油(2.5,1.25,0.625 g/kg)对于环磷酰胺(Cy)化疗及60Co放疗的减毒作用;通过小鼠碳廓清实验、血清溶血素测定实验检测药物对H22荷瘤小鼠免疫功能的影响。结果灵芝孢子油中高剂量组均可明显对抗由大剂量Cy、60Co照射造成的正常及荷瘤小鼠外周血WBC,骨髓有核细胞数,脾脏指数和胸腺指数下降(P<0.01,P<0.05)。灵芝孢子油各剂量均可显著提高荷瘤小鼠吞噬系数α,中高剂量组可明显提高荷瘤小鼠的血清半数溶血值(P<0.01,P<0.05)。结论灵芝孢子油可减低Cy和60Co所致的骨髓抑制毒性,并可显著提高小鼠细胞和体液免疫功能。
Objective To study the effects of G. lucidum spores oil on reducing the toxicity of the radiochemotherapy and enhancing the function of immune system in mice. Methods Study the effect of G. lucidum spores oil （ at the dose of 2.5,1.25,0. 725 g/kg） on reducing the toxicity of the Cy chemotherapy and ^60Co radiotherapy by detecting the number of the peripheral blood leucocyte, the number of bone marrow karyota; spleen index, thymus index of normal mice and H22 - bearing mice by carbon clearance test and serum erythrocytolysin test. Results It showed that G. lucidum spores oil at high （2.5 g/kg） and middle dose （ 1.25 g/kg） could significantly relieve the decrease of the number of the peripheral blood leucocyte, the number of bone marrow karyota, spleen index and thymus index of normal mice and tumop-bearing mice by Cy at a high dose and ^60Co （P 〈 0. 01, P 〈 0. 05）. G. lucidum spores oil at each dose could significantly increase macrophage phagocytic index; and at high and middle dose it can significantly enhance the serum erythrocytolysin level of H22 - bearing mice （ P 〈 0. 01, P 〈 0. 05 ）. Conclusion G. lucidum spores oil could relieve the myelosuppression caused by Cy and 60 Co; enhance the cellular and humoral immune function of tumor H22 -bearing mice.
出处
《时珍国医国药》
CAS
CSCD
北大核心
2006年第11期2179-2181,共3页
Lishizhen Medicine and Materia Medica Research
