摘要
目的探讨川芎嗪对小鼠黑色素瘤肺转移的抑制和iNOS、NO表达的增强作用。方法用黑色素瘤B16-F1细胞接种C57BL/6J小鼠造模,川芎嗪注射液100、200mg/(kg·d)灌胃20d后,检测小鼠肺、脾重量及血清iNOS和NO含量,计数其肺表面转移瘤结节数。结果川芎嗪能减少小鼠肺转移灶数目,增加其血清iNOS和NO含量。结论川芎嗪能抑制小鼠黑色素瘤的肺转移,机制可能与增强iNOS的表达和NO的合成有关。
[Objective] To explore the role of tetramethylpyrazine on inhibition of melanoma lung metastasis and enhance the expression of iNOS and NO. [Methods] The C57BL/6J mice bearing melanoma B16-F1 cells were intragastric with tetramethylpyrazine 100, 200 mg/（kg·d） for 20 days, then the weight of lungs, spleens, the number of the metastatic nodules on lungs and the levels of iNOS and NO in serum were detected. [Results] Tetramethylpyrazine could remarkably reduce the number of metastatic nodules on lungs, increase the expression of iNOS and NO in serum of the mice. [Conclusion] Tetramethylpyrazine can remarkably inhibit melanoma metastasis to lungs in the mice, Its mechanism may be correlated with enhancing the expression of iNOS and the synthesis of NO.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第21期3208-3210,共3页
China Journal of Modern Medicine
基金
湖北省科技厅资助项目(2003ABA145)
