摘要
本文测定了冷暴露条件下离体的、在体的和局部冻伤的大白鼠血浆中冷凝蛋白（ＣＩＰ）的含量，结果表明低温和局部冻伤均可促使血浆中ＣＩＰ含量显著升高（与常温对照组比，Ｐ＜０．０１）。实验结果提示ＣＩＰ为一种冷致性水不溶的大分子蛋白质，可能是一类与纤维粘连蛋白（ｆｉｂｒｏｎｅｃｔｉｎ）有关的蛋白。推想血浆中ＣＩＰ过量形成可能是导致冻伤组织血液循环障碍，形成微血栓的原因之一。
n this study,the cold-insoluble proteins(CIP)formed in rat plasma after cold stresswere determined,isolated and characterized.It is suggested that cold stimulation can in-crease the content of CIP in rat plasma significantly.CIP is a water-insoluble proteinwith large molecular weight,possibly a complex related to fibronectin(Fn ).CIP in plasmamay be one of the factors causing micro thrombi and blocking blood circulation in the cold in-jured tissues.
出处
《解放军预防医学杂志》
CAS
北大核心
1996年第4期257-260,共4页
Journal of Preventive Medicine of Chinese People's Liberation Army
关键词
冷凝蛋白
冷暴露
血浆
分离鉴定
cold insoluble proteins,cold exposure,plasma,isolation and characteri-zation
