摘要
多巴胺D2受体的拮抗解离假说是继5HT/DA平衡拮抗学说之后产生的又一试图解释第2代抗精神病药物作用机理的学说,本文就其产生的背景和意义作一介绍。
出处
《国际精神病学杂志》
2006年第4期196-199,共4页
Journal Of International Psychiatry
参考文献13
-
1Meltzer HY. Clinical studies on the mechanism of action of clozapine: the dopamine-serotoninhypothesis of schizophrenia.Psychopharmacology, 1989; 99: S18-S27.
-
2Meltzer HY, Matsubara S, Lee J. Classification of typical and atypical antipsychotic drugs on the basis of dopamine D-1, D-2 and serotonin2 Pki values. J Pharmacol Exp Ther. 1989; 251 :238-246.
-
3Kapur S, Remington G. Dopamine D2 receptors and their role in atypical antipsychotic action: Still necessary and may even be sufficient. Biol Psychiatry, 2001; 50: 873- 883.
-
4久住一郎,小山司.ドバミンD2受容体のfast dissociation反說をゃぐつて.臨床精神医学,2005,34(4):453-458
-
5Seeman P. Atypical antipsychotics: mechanism of action. Can J Psychiatry, 2002; 47 : 27 - 38.
-
6Garris PA, Wightman RM. Different kinetics govern dopaminergic transmission in the amygdala, prefrontal cortex and striatum,an in vivo voltammetry study. J Neurosci. 1994; 14: 442-450.
-
7Koepp M J, Gunn RN, Lawrence AD, et al. Evidence for striatal dopamine release during a video game. Nature, 1998;393 : 266-268.
-
8Kapur S, Zipursky R, Jones C, et al. A positron emission tomngraphy study of quetiapine in schizophrenia A preliminary finding of an antipsychotic effect with only transiently high dopamine D2 receptor occupancy. Arch Gen Psychiatry, 2000;57:553 - 559.
-
9Seeman P, Tallerico T. Rapid release of antipsychotic drugs from dopamine D2 receptors; An explanation for low receptor occupancy and early clinical relapse upon withdrawal of clozapine or quetiapine. Am J Psychiatry, 1999; 156: 876- 884.
-
10黑木俊秀.セロトニン·ドバミン反說の现在.臨床精神医学,2005;34(4):441~451
同被引文献15
-
1梁海翔.双相障碍的药物治疗[J].中国行为医学科学,2005,14(7):671-672. 被引量:8
-
2王继军,张明岛.精神分裂症的DUP[J].上海精神医学,2005,17(6):356-359. 被引量:19
-
3张明园.精神科评定量表专辑[J].上海精神医学,1990,2:2-2.
-
4颜文伟.KAY阳性阴性症状量表(PANSS).上海精神医学,1990,2:17-18.
-
5范肖冬 汪向东 于欣 译.ICD-10精神与行为障碍分类[M].北京:人民卫生出版社,1993.197.
-
6张明园.精神科评定量表手册[M].长沙:湖南科学技术出版社,2003.39.
-
7陆峥,蔡军,江开达,陈静,姚培芬,沈婷,王勇.典型和非典型抗精神病药合并碳酸锂治疗双相情感障碍躁狂发作的对照研究[J].上海精神医学,2007,19(3):142-144. 被引量:22
-
8西田淳志,冈崎佑士.统合失调症の早期支援·治疗[J].临床精神医学,2007,36(1):73-81.
-
9International Early Psychosis Association Writing Group. International clinical practice guidelines for early psychosis[J]. Br J Psychiatry, 2005, 187(Suppl 48) : 120-124.
-
10正木秀和,西川彻.统合失调症の治疗蘂开発研究[J].临床精神医学,2007,36(1):43-51.
二级引证文献6
-
1朱德超.比较利培酮与氯氮平对男性首发精神分裂症患者认知功能及社会功能的影响[J].中国药物经济学,2017,12(8):77-79. 被引量:3
-
2于杰.喹硫平联合碳酸锂对躁狂症的治疗价值评析[J].中国现代药物应用,2017,11(22):117-118. 被引量:1
-
3张强,王明洪,谢镇延.帕罗西汀联合奥氮平治疗精神分裂症伴抑郁的疗效观察[J].实用临床医药杂志,2017,21(24):96-97. 被引量:24
-
4刘超.利培酮联合碳酸锂治疗分裂情感性精神病的效果分析[J].中国医药指南,2018,16(25):163-164.
-
5寇轩粉.喹硫平和氨磺必利治疗康复期精神分裂症患者疗效比较[J].实用中西医结合临床,2020,20(1):51-52. 被引量:6
-
6李勃,孟娟.喹硫平与氯氮平分别联合碳酸锂治疗狂躁性精神分裂症的效果及安全性[J].临床医学,2022,42(2):115-116. 被引量:4
-
1刘俊丽,夏亮,王莉颖,田菲,翟明珠,鲁亚成,李云庆,朱霞.条件性回避反应在抗精神病药物筛选中的应用研究进展[J].神经解剖学杂志,2012,28(4):423-426.
-
2赵焕英,段德义,张智,徐群渊,杨慧.人胚胎脑多巴胺D_2受体基因的克隆[J].首都医科大学学报,2002,23(1):1-5. 被引量:2
-
3Fu-rong HAN,Hai WANG.Modulation by desensitized nicotinic receptors on metabolism of DA in striatum derived from the hemiparkinsonian model[J].中国应用生理学杂志,2016,32(6):487-493.
-
4赵焕英,赵春礼,鲁玲玲,鲁强,刘延英,杨慧.Ⅱ型人多巴胺受体逆转录病毒载体的构建及表达[J].解剖学报,2005,36(4):356-360.
-
5张淑贞,邵炜,周嘉伟.星形胶质细胞表达的多巴胺D2受体在抑制神经炎症反应中的作用[J].中国细胞生物学学报,2013,35(2):119-122. 被引量:4
-
6神经炎症研究的新成果[J].中国科学院院刊,2013,28(1):100-100.
-
7乐言.多巴胺D2受体决定星形胶质细胞作用的两面性[J].科学,2013,65(1):13-13.
-
8Kwang Taek Kim,Kyung Jin Chung,Han Sae Lee,Il Gyu Ko,Chang Ju Kim,Yong Gil Na,Khae Hawn Kim.Neuroprotective effects of tadalafil on gerbil dopaminergic neurons following cerebral ischemia[J].Neural Regeneration Research,2013,8(8):693-701. 被引量:1
-
9黄滨滨,郭艳红,徐佳,蔡英杰.综合干预方式联合二甲双胍治疗抗精神病药物所致体重增加的研究[J].黑龙江科技信息,2016(7):47-47.
-
10霍塞虎.多巴胺D2受体基因及其多态性与物质依赖的相关研究[J].健康研究,2009,29(3):214-218. 被引量:1