摘要
目的 建立一种简便、快速测定片剂中盐酸奥扎格雷含量的反相高效液相色谱分析方法。方法 采用Diamonsil C18（200mm×4．6mm，5μm）色谱柱，甲醇1％HAc（10：90）为流动相，流速为1mL·min，在274nm波长处进行检测。结果 辅料对测定无干扰，线性范围为10-200mg·L^1（r=0．9998）；样品的平均回收率为99．4％～100．1％，RSD为0．7％-0．9％。结论 方法简单、准确，可用于盐酸奥扎格雷片剂的含量测定。
Objective To develop a RP-HPLC method for the determination of ozagrel hydrochloride content in Ozagrel Hydrochloride Tablets. Methods Ozagrel hydrochloride was separated by using a column of Diamonsil C18（200 mm×4.6 mm,5 μm） and a mobile phase of methanol-1 % acetic acid （10 ： 90） at a flow rate of 1 mL· min^-1 with UV detector wavelength set at 274 nm. Results Ozagrel hydrochloride can be well seperated from other components, with the linear range of 10-200 mg· L^-1. The mean recovery of ozagrel hydrochloride was 99.4%-100.1% ,RSD was 0.6% - 0.9%. Conclusion This method is simple,accurate and can be used to control the quality of Ozagrel Hydrochloride Tablets.
出处
《西北药学杂志》
CAS
2006年第6期243-244,共2页
Northwest Pharmaceutical Journal
